| Eligibility |
Inclusion Criteria:
I1. Male or female patient =18 years of age at time of informed consent form signature.
I2. Histologically proven advanced/metastatic HNSCC (oropharynx, oral cavity, hypopharynx
and larynx). Patients with cancer of nasopharynx (i.e. cavum cancer) are not eligible.
I3. Documented radiological progression or relapse after platinum-containing systemic
therapy in the advanced/metastatic setting. Patients may have received anti-EGFR agents (in
combination or sequential) and other standard first-line treatment for metastatic HNSCC
available at time of enrolment.
I4. Documented tumor HPV status (positive and negative are eligible) based on p16 IHC
testing by local testing.
I5. Measurable disease at baseline according to RECIST V1.1. Note: Lesions intended to be
biopsied should not be defined as target lesions. I6. Availability of a representative
formalin-fixed paraffin-embedded (FFPE) primary and/or metastatic tumor tissue with an
associated pathology report from an archival block.
I7. Optional : Tumor lesion visible by medical imaging and accessible to repeatable
percutaneous or endoscopic sampling that permits core needle biopsy without unacceptable
risk of a significant procedural complications, and suitable for retrieval of 4 cores with
a needle minimum diameter :16-gauge.
I8. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. I9. Life
expectancy > 18 weeks.
I10. Adequate hematologic and end-organ function, defined by the following laboratory test
results, obtained within 7 days prior to C1D1:
- Bone marrow (without transfusion within 2 weeks before C1D1)
- WBC = 2.5 x 109/L
- Hemoglobin = 9.0 g/dL. Patients may be transfused (> 2 weeks before C1D1) to meet
this criterion.
- Absolute neutrophil count (ANC) = 1.5 x 109/L without granulocyte
colony-stimulating factor support within 2 weeks before C1D1.
- Platelets = 100 x 109/L
- Lymphocyte count = 0.5 x 109/L
- Renal function
-Serum creatinine clearance =30 mL/min/1.73m2 (MDRD or CKD-EPI formula) or serum
creatinine =1.5ULN.
- Hepatic function
- Serum bilirubin = 1.5 × Upper Limit of Normal (ULN), with the following
exception: Patients with known Gilbert disease who have serum bilirubin level = 3
x ULN may be enrolled.
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline
phosphatase (ALP) = 2.5 x ULN, with the exceptions of patients with liver
involvement for whom AST and/or ALT and/or PAL = 5 ULN is acceptable.
- Coagulation
- Prothrombin time/INR = 1.5, or, if patient is receiving therapeutic
anticoagulation, prothrombin time/INR < 3.0
- aPTT = ULN OR, if patient is receiving therapeutic anticoagulation, aPTT must be
< 1.5 ULN.
- Proteinuria by urine dipstick < 2+ or 24-hour proteinuria = 1.0 g. I11. Women patients
of child-bearing potential are eligible, provided they have a negative serum or urine
pregnancy test within 7 days prior to C1D1, and agrees to use adequate contraception
(for example, intrauterine device [IUD], birth control pills unless clinically
contraindicated, or barrier device) beginning 2 weeks before the first dose of study
drugs and for up to 6 months after the final dose of study drugs.
I12. Fertile men must agree to use an effective method of contraception during the study
and for up to 6 months after the last dose of study drugs.
I13. Patient should understand, sign, and date the written voluntary informed consent form
prior to any protocol-specific procedures performed and should be able and willing to
comply with study visits and procedures as per protocol.
I14. Patients must be covered by a medical insurance in country where applicable.
Exclusion Criteria:
E1. Malignancies other than HNSCC within 3 years prior to C1D1 with the exception of those
with a negligible risk of metastasis or death and treated with expected curative outcome
(such as adequately treated carcinoma in situ of the cervix, basal or squamous cell skin
cancer, localised prostate cancer or ductal carcinoma in situ treated surgically with
curative intent).
E2. More than two prior lines of systemic therapy for recurrent or metastatic HNSCC.
E3. Symptomatic, untreated, or actively progressing central nervous system (CNS)
metastases.
Note: Asymptomatic patients with treated CNS lesions are eligible, provided that all of the
following criteria are met:
- Measurable disease, per RECIST v1.1, must be present outside the CNS.
- The patient has no history of intracranial hemorrhage or spinal cord hemorrhage.
- Metastases are limited to the cerebellum or the supratentorial region (i.e., no
metastases to the midbrain, pons, medulla, or spinal cord).
- There is no evidence of interim progression between completion of CNS-directed therapy
and initiation of study treatment.
- The patient has not undergone stereotactic radiotherapy within 7 days prior to
initiation of study treatment, whole-brain radiotherapy within 14 days prior to
initiation of study treatment, neurosurgical resection within 28 days prior to
initiation of study treatment.
- The patient has no ongoing requirement for corticosteroids as therapy for CNS disease.
Anticonvulsant therapy at a stable dose is permitted.
- Asymptomatic patients with CNS metastases newly detected at screening are eligible for
the study after receiving radiotherapy or surgery, with no need to repeat the
screening brain scan.
E4. Evidence of tumor lesion is hemorrhagic or radiographic evidence of major blood vessel
invasion/infiltration of tumor demonstrating >90° abutment or encasement of a major blood
vessel.
E5. Spinal cord compression not definitively treated with surgery and/or radiation.
E6. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent
drainage procedures.
E7. Uncontrolled tumor pain.
- Patients who require narcotic pain medication during screening should be on a stable
dose regimen prior to C1D1.
- Symptomatic lesions (e.g., bone metastases or metastases causing nerve impingement)
amenable to palliative radiotherapy should be treated prior to C1D1. Patients should
be recovered from the effects of radiation. There is no required minimum recovery
period.
- Asymptomatic metastatic lesions that would likely cause functional deficits or
intractable pain with further growth (e.g., epidural metastasis that is not currently
associated with spinal cord compression) should be considered for loco-regional
therapy if appropriate prior to enrollment.
E8. Acute and ongoing toxicities from previous therapy that have not resolved to Grade = 1,
except for alopecia, neuropathy and lab values presented in inclusion criteria.
E9. Prior treatment with CD137 agonists or immune checkpoint blockade therapies (including
PD-1 and PD-L1, CTLA4 inhibitors), or with VEGF/VEGFR inhibitors.
E10. Prior allogeneic bone marrow transplantation or solid organ transplant for another
malignancy in the past.
E11. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to C1D1, or abdominal surgery, abdominal interventions or significant abdominal
traumatic injury within 60 days prior to C1D1 or anticipation of need for major surgical
procedure during the course of the study or non-recovery from side effects of any such
procedure.
E12. Prior radiation therapy within 21 days prior to C1D1 and/or persistence of
radiation-related Grade > 1 AE (including CNS radiotherapy and palliative radiotherapy
according to E3 and E8).
E13. Treatment with any investigational agent or approved anti-cancer therapy within 28
days or five investigational agent half-lives (whichever is longer) prior to C1D1.
E14. Treatment with systemic immunosuppressive medication (including, but not limited to,
corticosteroids, cyclophosphamide, azathioprine, methotrexate, thalidomide, and
anti-TNF-alpha agents) within 2 weeks prior to C1D1, or anticipation of need for systemic
immunosuppressive medication during study treatment; with the exceptions of
intranasal,inhaled or topical corticosteroids or systemic corticosteroids at physiological
doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid.
E15. Systemic immunostimulatory agents (including, but not limited to, interferons and
IL-2) are prohibited within 4 weeks or five half-lives of the drug (whichever is longer)
prior to C1D1.
E16. Oral or IV antibiotics within 14 days of C1D1. Note: Patients receiving prophylactic
antibiotics (e.g., to prevent a urinary tract infection or chronic obstructive pulmonary
disease exacerbation) are eligible.
E17. Use within 10 days prior to C1D1 of the following treatment:
- Acetylsalicylic acid (> 325 mg/day) (Note: lower dose is acceptable before and during
the treatment period).
- Clopidogrel (> 75 mg/day) (Note: lower dose is acceptable before and during the
treatment period)
- Therapeutic oral or parenteral anticoagulants or thrombolytic agents for therapeutic
purposes except if INR or aPTT is within therapeutic limits (according to the medical
standard of the enrolling institution) and the patient has been on a stable dose of
anticoagulants for at least 2 weeks at C1D1.
E18. History of severe allergic or other hypersensitivity reactions to:
- chimeric or humanized antibodies or fusion proteins,
- biopharmaceuticals produced in Chinese hamster ovary cells, or
- any component of the Atezolizumab or Bevacizumab formulations E19. Concurrent
treatment with any other anti-cancer treatment, approved or investigational agent or
participation in another clinical trial with therapeutic intent.
E20. History of autoimmune disease including but not limited to myasthenia gravis,
myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis,
inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome,
Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barre syndrome, multiple sclerosis,
vasculitis, or glomerulonephritis with the following exceptions:
- patients with a history of autoimmune-related hypothyroidism who are on thyroid
replacement hormone,
- patients with controlled Type 1 diabetes mellitus,
- patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with
dermatologic manifestations only (e.g., patients with psoriatic arthritis would be
excluded) are permitted provided that they meet the following conditions:
- rash must cover less than 10% of body surface area (BSA).
- disease is well controlled at baseline and only requiring low potency topical
steroids.
- no acute exacerbations of underlying condition within the previous 12 months
requiring PUVA (Psoralen plus Ultraviolet A radiation), methotrexate, retinoids,
biologic agents, oral calcineurin inhibitors, high-potency or oral steroids"
E21. Infectious diseases :
- active infection requiring IV antibiotics,
- severe infection within 4 weeks prior to C1D1, including, but not limited to,
hospitalization for complications of infection, bacteremia, or severe pneumonia,
- active hepatitis B (chronic or acute; defined as having a positive hepatitis B surface
antigen [HBsAg] test at screening), Note : Patients with past hepatitis B virus (HBV)
infection or resolved HBV infection (defined as the presence of hepatitis B core
antibody [anti-HBc] and absence of HBsAg) are eligible. HBV DNA test must be performed
in these patients prior to C1D1.
- active hepatitis C. Patients positive for hepatitis C virus (HCV) antibody are
eligible only if PCR is negative for HCV RNA at screening
- HIV infection,
- active tuberculosis
- influenza vaccination should be given during influenza season. Patients must not
receive live attenuated influenza vaccine (e.g., FluMist®) within 4 weeks prior to
C1D1 or at any time during the study.
E22. Significant cardiovascular disease :
- Significant cardiovascular disease, such as New York Heart Association cardiac disease
(Class II or greater), myocardial infarction within 3 months prior to C1D1, unstable
arrhythmias, acute coronary syndromes (including unstable angina), or history of
coronary angioplasty/stenting/bypass grafting within past 6 months.
- Left Ventricular Ejection Fraction (LVEF) < 40% at screening.
- Known coronary artery disease, congestive heart failure not meeting the above
criteria, or LVEF < 50% must be on a stable medical regimen that is optimized in the
opinion of the treating physician, in consultation with a cardiologist if appropriate.
- Severe cardiac arrhythmia requiring medication or severe conduction abnormalities
- Clinically significant valvular disease, cardiomegaly, ventricular hypertrophy, or
cardiomyopathy.
- Uncontrolled hypertension defined by systolic pressure > 150 mm Hg and/or diastolic
pressure > 100 mm Hg, with or without anti-hypertensive medication. Patients with
initial blood pressure elevations are eligible if initiation or adjustment of
anti-hypertensive medication lowers blood pressure to meet entry criteria.
- Prior history of hypertensive crisis or hypertensive encephalopathy
- History of stroke or transient ischemic attack within 6 months prior to C1D1
- Clinically significant peripheral vascular disease (e.g., aortic aneurysm requiring
surgical repair or recent peripheral arterial thrombosis) within 6 months prior to
C1D1.
E23. History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced
pneumonitis, organizing pneumonia (i.e. bronchiolitis obliterans, cryptogenic organizing
pneumonia), or evidence of active pneumonitis on screening chest CT scan.
E24. History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
within 6 months prior to C1D1.
E25. Serious non-healing wound, active ulcer or untreated bone fracture. E26. History of
hemoptysis (= ½ teaspoon of bright red blood per episode), or any other serious hemorrhage
or at risk of bleeding (gastrointestinal history of bleeds, gastrointestinal ulcers, etc.).
E27. History or evidence of inherited bleeding diathesis or significant coagulopathy at
risk of bleeding.
E28. Evidence of significant uncontrolled concomitant disease that could affect compliance
with the protocol or interpretation of results, including significant liver disease (such
as cirrhosis, uncontrolled major seizure disorder, or superior vena cava syndrome).
E29. Pregnant or lactating women.
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