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Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer — ROOCT  

Head and Neck Cancer Clinical Trial

Official title:
Live Laser Microscopic Evaluation (OCT) of Radiation Induced Preclinical Alterations of the Skin in Head and Neck Cancer Patients

Clinical Trial Summary

The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT). Another key question is whether subclinical OCT detected skin damage correlates with acute and late clinical toxicity.

Clinical Trial Description

Head and neck cancer patients that meet the eligibility criteria and singned the informed consent will undergo OCT-measurements before, during and after the course of radiation therapy. At the same time-points the skin areas are evaluated with dermatoscopy and patients are asked to self-assess their quality of life (EORTC QLQ C30 and respective head and neck module H&N 43). Before the onset of radiation therapy radiation sensitivity analysis will be performed with in-vitro irradion of peripheral blood lymphocytes (FISH). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04610645
Study type Observational
Source Krankenhaus Barmherzige Schwestern Linz
Contact Elisabeth Silberberger, MSc
Phone +43 (732) 7677
Email elisabeth.silberberger@ordensklinikum.at
Status Recruiting
Phase
Start date June 8, 2020
Completion date December 8, 2026
View Details
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