Infection Clinical Trial
Official title:
Split Thickness Skin Graft Take and Microbiology Evaluation in Burned Patients
SPLIT-THICKNESS SKIN GRAFT TAKE AND MICROBIOLOGICAL EVALUATION IN BURNED PATIENTS
INTRODUCTION: Infection is cause of increased morbidity and mortality in burn patients, and
its control is a major challenge also for skin graft integration. Wound and soft tissue
infection rates are higher than microbiological diagnosis rates.
PURPOSE: To evaluate partial skin graft integration in relation to microbiological analysis
of wounds in burn patients.
METHODS: This project will be a transversal, prospective, analytical, controlled study in
humans, conducted in a single center, at Burn Care Unit of Department of Plastic Surgery at
Federal University of São Paulo from October, 2010 to October, 2011. Data will be collected
to characterize demographic and clinical aspects. Data analysis will be performed using
Student's t-test and Friedman analysis of variance.
SPLIT-THICKNESS SKIN GRAFT TAKE AND MICROBIOLOGICAL EVALUATION IN BURNED PATIENTS
INTRODUCTION: Early excision and partial skin graft is state-of-the-art in burns treatment.
Otherwise, infection is cause of increased morbidity and mortality in burn patients, and its
control is a major challenge also for skin graft integration. Wound and soft tissue
infection rates are higher than microbiological diagnosis rates. This difference is related
to moderate sensibility of cultures in general. Precise bacterial diagnostic and its
susceptibility to specific antibiotics are prerequisite for adequate treatment of burn
patients and skin graft integration.
PURPOSE: To evaluate partial skin graft integration in relation to microbiological analysis
of wounds in burn patients.
METHODS: This project was approved at Ethics Committee at Federal University of São Paulo
(1272/10). It will be a transversal, prospective, analytical, controlled study in humans,
conducted in a single center, at Burn Care Unit of Department of Plastic Surgery at Federal
University of São Paulo from October, 2010 to October, 2011. Thirty patients will be
included in this study after reading and signing a consent form. Data will be collected
using an evaluation sheet to characterize demographic and clinical aspects, including
partial skin graft integration, use of topical and systemic antibiotics and infection rates
in all sites (blood, urine, skin, tracheal aspirate and bronchial lavage). Data analysis
will be performed using Student's t-test and Friedman analysis of variance.
;
Observational Model: Case-Only, Time Perspective: Prospective
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