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Glucagon-like Peptide 2 - a Glucose Dependent Glucagonotropic Hormone? — GLANCE  

Glucose Metabolism Disorders Clinical Trial

Official title:
Glucagon-like Peptide 2 - a Glucose Dependent Glucagonotropic Hormone?

Clinical Trial Summary

Infusion of glucagon-like peptide 2 (GLP-2) during euglycaemia, hypoglycaemia and hyperglycaemia and evaluation of the effect on glucagon secretion in healthy subjects.

Clinical Trial Description

This is a cross-over, randomized, double-blinded study in which 10 participants will undergo 6 experimental days each. The participants will have their plasma glucose clamped at either euglycaemia (fasting level), hypoglycemia (2,5 mmol/l) or hyperglycemia (10 mmol/l) during infusion of GLP-2 or saline (placebo) The six days will be as follows: - Euglycaemia + Placebo - Euglycaemia + GLP-2 - Hyperglycaemia + Placebo - Hyperglycaemia + GLP-2 - Hypoglycaemia + Placebo - Hypoglycaemia + GLP-2 The primary endpoint will be levels of plasma glucagon. Secondary endpoint will be levels of GLP-1, GLP-2, Insulin/C-peptide, OXM, Amino acids, CCK, Gastrin, norepinephrine, bile acids, FGF-19/FGF-21. Secondary endpoints will also include ultrasound scan of the gallbladder. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03954873
Study type Interventional
Source University Hospital, Gentofte, Copenhagen
Contact
Status Completed
Phase N/A
Start date January 31, 2019
Completion date June 1, 2020
View Details
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