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Glucose Metabolism Disorders clinical trials

View clinical trials related to Glucose Metabolism Disorders.

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NCT ID: NCT06295640 Recruiting - Clinical trials for Glucose Metabolism Disorders

Relative Contribution of Brain Insulin Action for Postprandial Metabolism

BrainInsPPM
Start date: March 15, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to clarify (i) the contribution of brain insulin action on regulation of systemic metabolism, (ii) sex-specific differences in the central regulation and (iii) the influence of the menstrual cycle in women. Therefore, participants will undergo oral glucose tolerance tests combined with a double tracer dilution technique. This approach will be compared between days with insulin delivery to the brain as nasal spray and days with placebo spray.

NCT ID: NCT06260254 Recruiting - Sleep Disturbance Clinical Trials

Effects of Railway Vibration on Sleep and Disease

BioVib
Start date: February 5, 2024
Phase: N/A
Study type: Interventional

This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.

NCT ID: NCT06145360 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient

Start date: December 31, 2023
Phase: Phase 4
Study type: Interventional

The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4 (DPP-4) inhibitors in poorly controlled type 2 diabetes mellitus (T2DM) patients. The study seeks to evaluate its effect on achieving glycemic goals in this patient population.

NCT ID: NCT05874635 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)

Start date: May 11, 2023
Phase: N/A
Study type: Interventional

The use of continuous glucose monitoring (CGM) in earlier data has inspired behavioral changes leading to improved adherence to an exercise plan in individuals and eating habits in people with diabetes. Mobile health (mHealth) platforms provide satisfactory, easy-to-use tools to help participants in the pursuit of weight change goals. We hypothesize that the use of CGM data and the Signos mHealth platform will assist with weight control in a population of people with type 2 diabetes mellitus who are not using insulin.

NCT ID: NCT05779644 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus

Start date: February 23, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to analyze the effects of GLP-1RA on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.

NCT ID: NCT05748444 Recruiting - Cystic Fibrosis Clinical Trials

The Relationship Between Diet and Glycemic Response and Inflammatory Markers in Children With Cystic Fibrosis

Start date: January 1, 2023
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to determine the relationship between diets of children with cystic fibrosis and glycemic responses and some inflammatory markers.

NCT ID: NCT05726461 Recruiting - Diabetes Mellitus Clinical Trials

Efficacy and Safety of Android Artificial Pancreas System in Adult Patients With Type 1 Diabetes Mellitus in China

Start date: February 11, 2023
Phase: N/A
Study type: Interventional

This is a 26-week randomized, free-living, open-label, two-arm, two-phase, crossover trial. Participants will receive two interventions at different phases, including the Android artificial pancreas system(AndroidAPS-rt-CGM) and sensor-augment pump(SAP), and use marketed rapid-acting insulin analogs (insulin Aspart, insulin Lispro, or insulin Glulisine) normally used in their usual clinical care. The safety and efficacy of AndroidAPS-rt-CGM and SAP in adult T1DM with suboptimal glycemic control will be compared to explore whether the use of AndroidAPS-rt-CGM in adult T1DM with suboptimal glycemic control will be associated with better glycemic control with no increased hypoglycemia.

NCT ID: NCT05695235 Recruiting - Sleep Clinical Trials

Monitoring Sleep, Wellbeing, and Glucose Metabolism in PGY1s

Start date: January 1, 2022
Phase:
Study type: Observational

Overnight on-call schedules can impact sleep, wellbeing, and alertness, which can be detrimental on the performance, physical and mental health of residents. Moreover, rotating shift work may have a long-term negative health impact (e.g. increased risk of diabetes). Within the National University Hospital (NUH), two different systems of rotating on-call schedules are implemented. In the night float system, residents work from 8 pm to 8 am for 5 - 7 consecutive nights once every month, compared to the traditional overnight on-call system, where each resident is on call for 4-6 nights per month (7 am - 5 pm, followed by overnight call until 8 am the next morning). The aim of the current study is to track sleep, wellbeing, and glucose metabolism during the different phases of the night float and traditional on-call schedules.

NCT ID: NCT05565248 Recruiting - Diabetes Mellitus Clinical Trials

An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D

Start date: January 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, multicenter, Phase 1/2 study evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects with T1D

NCT ID: NCT05544266 Recruiting - Diabetes Mellitus Clinical Trials

Rare and Atypical Diabetes Network

RADIANT
Start date: September 30, 2020
Phase:
Study type: Observational

RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes. 3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes.