Glioma Clinical Trial
Official title:
Prospective Study of Awake Intraoperative Language Mapping and Construction of Chinese Probabilistic Map Based on Direct Electrical Stimulation
The study aims at constructing a Chinese language probabilistic map by awake intraoperative direct electrical stimulation (DES) language mapping. At the same time, the standardization and optimization of awake intraoperative DES parameters will be explored, factors affecting postoperative function morbidity and survival will also be analyzed.
The study aims at constructing a Chinese language probabilistic map by awake intraoperative
direct electrical stimulation (DES) language mapping.
The "maximal safe resection" of brain tumor adjacent to language cortex requires precise
real-time localization of the intraoperative language cortex.
Awake craniotomy combined with DES to localize language cortex has been carried out for
several decades. However, there is yet no unified standard on the specification of its
technical parameters. Besides, language probabilistic maps based on DES have been reported by
several teams around the world. However these studies were based on the Indo-European
language speakers alone. There was one paper published in 2015 by the investigators' group
using DES for the Chinese probabilistic map, but it is also a single center study, and the
sample size is relatively small.
Awake craniotomy and intraoperative DES for language cortex localization will be used to
construct a Chinese probabilistic map in this study. Several common tasks for language
mapping (i.e., number counting, picture naming, word reading) will be applied in Chinese
speakers. The positive language sites including speech arrest, anomia, alexia, anarthria,
dysarthria, semantic paraphasia and phonological paraphasia, spatial negativity and other
higher order cognitive function will be identified in individual patients and normalized to
the standard brain atlas. The corresponding probabilistic maps will be integrated and
generated.
At the same time, the standardization and optimization of awake intraoperative DES parameters
will be explored, factors affecting postoperative function morbidity and survival will also
be analyzed.
Through this study, the investigators will further popularize individualized awake surgery of
glioma in language cortex, improve the extent of tumor resection, protect postoperative
language function and improve postoperative quality of life. By constructing this
standardized Chinese probabilistic map, the investigators will provide more direct evidence
for brain language research.
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