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Clinical Trial Summary

Bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), is an antiangiogenic treatment currently proposed to recurrent high grade glioma patients. Unfortunately some patients fail to respond to this treatment and finding biological factors allowing the discrimination between potential responders and non responders would be very helpful. As the immune system plays a key role in angiogenesis induction and maintenance in cancer, it could serve as a surrogate marker of angiogenesis in cancer patients.

The purpose of this study is to determine the influence of bevacizumab treatment on circulating immune cells in high grade glioma patients and to search for a link between the variation of these cells and the response to treatment.


Clinical Trial Description

The following leucocyte subsets will be analyzed in whole blood before treatment and before cycles 3, 5 and 7:

- Classical, intermediate, nonclassical and Tie2 expressing monocytes.

- Regulatory T cells (Treg).

- Myeloid Derived Suppressor cells (MDSCs) The variation of the absolute numbers (or relative percentages) of the cells in the blood of patients will be correlated to the response to treatment assessed according to the RANO criteria. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01836536
Study type Interventional
Source Center Eugene Marquis
Contact
Status Completed
Phase N/A
Start date September 2012
Completion date August 2015

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