Tafluprost Preservative Free Switch Study

Status Completed

Clinical Trial Summary

This study is conducted to document the effect of switching from preserved prostaglandin analogues monotherapy to preservative free tafluprost 0.0015%. The endpoints analyzed are side effect improvement in these patients.

Clinical Trial Description

Importance: Glaucoma medications are often preserved with agents such as benzalkonium chloride, which commonly lead to ocular surface diseases. Background: To investigate the effect of switching to a preservative-free prostaglandin analogue, tafluprost 0.0015% on treatment tolerability and ocular surface diseases. Design: This was a prospective, open label, non-randomised, observational study performed in a single hospital. Participants: Patients of Asian descent who have primary open angle glaucoma and ocular hypertension (n = 28), who received preserved prostaglandin monotherapy for longer than 3 months, and has a National Eye Institute ocular surface staining scale score higher than 1. Methods: Patients were switched from preserved prostaglandin monotherapy to preservative-free tafluprost 0.0015%. Patients were analysed at baseline (Visit 0), 1 month (Visit 1) and 3 months (Visit 2). Main Outcome Measures: The main parameter measured is the change in the fluorescein staining score at Visit 2. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04654611
Study type	Interventional
Source	Tun Hussein Onn National Eye Hospital
Contact
Status	Completed
Phase	Phase 4
Start date	February 1, 2019
Completion date	February 1, 2020

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