Clinical & Histomorphometric Analysis of Collagen Matrix Versus Connective

Status Recruiting

Clinical Trial Summary

There are some orthodontics treatments that perform risk movements ,and a bone dehiscence may be expected. In that cases mucogingival surgery , such as connective tissue grafts, is necessary prior to tooth movement.

The connective tissue graft in combination with coronal advanced flap is still considered the gold standard , although the use of porcine collagen matrix has obtained promising results for treatment of Miller class I and II recession defects.

Most of the studies report clinical results after a connective tissue graft and there is no evidence about the type of attachment obtained after the graft is performed, a few articles have shown histological results. But, as a rule , a histological study is only performed under exceptional circumstances such as a dental fracture, untreatable decay, tooth extraction for orthodontic reasons, or other reasons.

Most of the techniques results in the formation of a long junctional epithelium and connective tissue attachment with fibers parallel to the root surface. Animals studies have shown a shorter epithelium and a larger new cementum formation after the use of the collagen matrix.

Clinical Trial Description

The purpose of this study is to confirm that periodontal regeneration happens after mucogingival surgery The principal outcome is compare the millimeters of new attachment create after a connective tissue graft and after the use of a porcine collagen matrix in teeth that have to been extracted (because of the orthodontic planing treatment) after mucogingival surgery .

The secondary outcomes are:

1. length of new cementum (histometry results)

2. length of the junctional epithelium (histometry results)

3. length of connective tissue attachment (histometry results)

4. complete root coverage (clinical results)

5. width of keratinized tissue ;

Study Design

Related Conditions & MeSH terms

Gingival Recession

Clinical Trial Details

NCT number	NCT03533933
Study type	Interventional
Source	Basque Country University
Contact	Elena Ruiz de Gopegui
Phone	0034649547011
Email	helenruizdegopegui@gmail.com
Status	Recruiting
Phase	N/A
Start date	September 1, 2018
Completion date	June 1, 2022

View Details

See also
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Completed	`NCT03204565` - Effectiveness of Adjunctive Hyaluronic Acid Application in Coronally Advanced Flap in Single Gingival Recession Sites	N/A
Completed	`NCT01440426` - Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects	Phase 4
Completed	`NCT02129504` - Two Techniques for Root Coverage With a Xenogeneic Collagen Matrix	N/A
Completed	`NCT01547962` - A Pilot Clinical Trial of Gintuit (TM)in Establishing a Functional Zone of Attached Gingiva	N/A
Completed	`NCT04043039` - Platelet Rich Fibrin in the Treatment of Full Thickness Palatal Wounds	N/A
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Active, not recruiting	`NCT03570333` - Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites	N/A
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Active, not recruiting	`NCT05101642` - Guided Creeping Technique (GCT) in Treating Gingival Recession	N/A
Completed	`NCT04813302` - Influence of Anatomical Factors Upon Root Coverage	N/A
Recruiting	`NCT06006780` - Porcine Acellular Dermal Matrix for the Treatment of Localized Gingival Recessions A Multicenter Randomized Clinical Trial.	N/A
Enrolling by invitation	`NCT06330662` - Effectiveness of Hyaluronic Acid on Multiple Adjacent Gingival Recessions Using a Coronally Advanced Flap	N/A
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Recruiting	`NCT05563428` - Free Gingival Graft Versus Connective Tissue Graft	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Clinical and Histomorphometric Analysis of Collagen Matrix Versus Connective Tissue Graft in Mucogingival Surgery in Orthodontic Patients

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms