Fetal Growth Retardation Clinical Trial
Official title:
Phase 2 Study of Fetal Growth Retardation Treatment by Sildenafil
The purpose of this study is to determine whether sildenafil is effective and safe in the treatment of fetal growth restriction.
Fetal growth retardation affects up to 8% of all pregnancies and has massive short term
(increased fetal morbidity and mortality) and long-term (increased incidence of
cardiovascular disorders in adulthood) health implications.
Doppler waveform analysis of these pregnancies suggests compromised uteroplacental
circulation and placental hypoperfusion.
Our aim is to assess if sildenafil citrate could improve vasodilatation in FGR pregnancies.
Sildenafil citrate may offer a potential therapeutic strategy to improve uteroplacental
perfusion in FGR.
Animal studies suggest that phosphodiesterase-5 (PDE5) inhibitors, such as sildenafil
citrate, may improve uterine blood flow .
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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