Neuroblastoma Clinical Trial
Official title:
Haploidentical Stem Cell Transplantation Followed by NK Cell Infusion in Patients With High-risk Solid Tumors Who Failed Autologous Stem Cell Transplantation
To evaluate feasibility and efficacy of haploidentical stem cell transplantation in patients
with high-risk solid tumors who failed after tandem high-dose chemotherapy and autologous
stem cell transplantation.
To evaluate feasibility and efficacy of NK cell infusion after haploidentical stem cell
transplantation in patients with high-risk solid tumors who failed after tandem high-dose
chemotherapy and autologous stem cell transplantation.
HaploSCT following reduced-intensity conditioning (RIC) regimen will be performed in patients with high-risk solid tumors. Both parents will be evaluated for their KIR genotype and phenotype and the one with the greatest degree of KIR-L mismatch with the patient will be selected as the donor. In addition, ex-vivo expanded NK cells derived from the donor will then be administered after haploSCT to increase the GVT effect. Low-dose IL-2 will be given after expanded NK cell infusion to enhance NK cell alloreactivity. ;
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