Clinical Trials Logo

Essential Tremor clinical trials

View clinical trials related to Essential Tremor.

Filter by:
  • Withdrawn  
  • Page 1 ·  Next »

NCT ID: NCT06312800 Withdrawn - Essential Tremor Clinical Trials

Acamprosate and Methazolamide for Essential Tremor

Start date: March 2016
Phase: Phase 2
Study type: Interventional

This is an investigator initiated study is designed to evaluate the anti-tremor benefits of two marketed medications, methazolamide and acamprosate in subjects with a diagnosis of essential tremor (ET).

NCT ID: NCT05387642 Withdrawn - Essential Tremor Clinical Trials

A Clinical Trial of PRAX-114 in Participants With Essential Tremor

Start date: April 5, 2022
Phase: Phase 2
Study type: Interventional

This is a 2-part clinical trial to evaluate the safety, tolerability, pharmacokinetics, and efficacy of PRAX-114 in participants with essential tremor (ET). Part A is a randomized, double-blind, placebo-controlled, three-period, three-sequence, crossover design where participants will receive a single dose of 10 mg PRAX-114, 20 mg PRAX-114, and matching placebo. Part B is an open-label design where participants from Part A, after washout and confirmation of eligibility may elect to participate in Part B where all participants will receive 10 mg once every morning (QAM) for the first 14 days. Based on investigator judgement of the safety and tolerability, the dose for Days 15 to 28 could be increased to 20 mg QAM.

NCT ID: NCT05381688 Withdrawn - Essential Tremor Clinical Trials

VIM DBS Respiratory Modulation: N-of-1 Trial

Start date: September 9, 2021
Phase:
Study type: Observational

Research from our group has demonstrated modulation of PEFR in patients with STN and PAG stimulation. However, the effect of VIM (motor thalamus) stimulation remains to be investigated. Our group has also been involved in research that indicates that VIM stimulation may reduce perception of breathlessness. However, methodological factors limit the conclusions that can be drawn from this prior work. N-of-1 trials, organised as a randomised multiphase crossover design, are uniquely well suited for DBS research where stimulation can be switched ON and OFF, and with simple tests that can be done quickly, multiple times. PEFR and breath-holding are simple tests that we will test in this way. Other respiratory tests will be carried out along side, as optional, in a single phase design. We aim to offer this study to a continuous cohort of patients scheduled to undergo VIM (ET/DT) DBS at our institution. We will establish a pre-operative baseline of respiratory function, and then perform the n-of-1 trial post-operatively, soon after the patient returns to hospital to receive their DBS programming.

NCT ID: NCT04283812 Withdrawn - Parkinson Disease Clinical Trials

New Stereotactic Frame System for Neurosurgery

Start date: January 2023
Phase: N/A
Study type: Interventional

This study is designed to demonstrate an in-house developed re-attachable stereotactic system that can markedly reduce the overall deep brain stimulation (DBS) procedure time to greatly facilitate subject access to neurosurgical restorative therapies. Subjects will consist exclusively of individuals who have been approved to undergo deep brain stimulation surgery for the treatment of a neurological disorder at Mayo Clinic - Rochester MN. This study is a quantitative comparative, between-subject study enrolling approximately 10 subjects.

NCT ID: NCT02418858 Withdrawn - Essential Tremor Clinical Trials

Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor

Start date: February 2015
Phase: N/A
Study type: Interventional

Recently, there has been increasing interest in performing DBS under general anesthesia, where the stimulated targets are located anatomically (i.e. on MRI) rather than physiologically via microelectrode recordings and intra-operative test stimulation. This technology has been termed "asleep" DBS and is performed with the patient under general anesthesia. Intraoperative imaging is utilized to verify the stereotactic accuracy of DBS electrodes placement at the time of surgery. Because stereotactic accuracy (and surgical safety) is the surgical endpoint, there is no need for the patient to be awake during the procedure.

NCT ID: NCT01940406 Withdrawn - Parkinson Disease Clinical Trials

The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study

Start date: October 2013
Phase: N/A
Study type: Interventional

The current study is designed to test the hypothesis that targeted electrical stimulation will result in upper limb tremor reduction in ET and PD patients.

NCT ID: NCT01820390 Withdrawn - Parkinson's Disease Clinical Trials

Optimizing DBS Electrode Placement and Programming

Start date: March 2013
Phase: N/A
Study type: Observational

Deep brain stimulation (DBS) has become the primary surgical therapy for the treatment of motor symptoms associated with Parkinson's disease (PD), and for essential tremor (ET). Although an effective and relatively safe procedure with expanding indications, opportunities exist for the optimization of the current procedure. The investigators therefore propose, in a group of patients undergoing DBS surgery for the treatment of PD or ET, to use a combination of high‐field imaging modalities, intraoperative electrophysiology, external sensor interfaces, and computational modeling, to gather information on the utility of using these techniques to optimize DBS electrode placement and programming.

NCT ID: NCT01441284 Withdrawn - Essential Tremor Clinical Trials

Efficacy of Pramipexole Extended Release in the Treatment of Essential Tremor

Start date: December 2017
Phase: Phase 3
Study type: Interventional

Aim of the study is to perform a double-blind, crossover, placebo-controlled multicenter study evaluating the efficacy of pramipexole on essential tremor.

NCT ID: NCT00634478 Withdrawn - Essential Tremor Clinical Trials

Pre-lemniscal Radiation Deep Brain Stimulation for ET

Start date: October 2008
Phase: N/A
Study type: Interventional

The hypothesis is that prelemniscal radiation (RaPRL) deep brain stimulation (DBS) is more effective for axial (head/neck/voice) tremor, and perhaps, appendicular tremor control in essential tremor patients.

NCT ID: NCT00608231 Withdrawn - Parkinson's Disease Clinical Trials

Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation

Start date: January 2008
Phase: Phase 2/Phase 3
Study type: Interventional

To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings