Esophageal Atresia Clinical Trial
Official title:
High-resolution Esophageal Manometry in Teenagers With Esophageal Atresia
EA is one of the most frequent birth defects, with an incidence of 1 in 3000 live births1.
Until the 1950s, these patients had 100% mortality; nowadays, the survival rate is greater
than 90%, and only those with associated severe malformations die1-5.
Type C EA (atresia of the esophageal proximal segment with tracheoesophageal fistula between
the trachea and the distal segment) is the most common variant, since it is present in 85% of
the cases6-8. There is evidence that the esophageal motor disorder present in these children
is secondary to a congenital neuromuscular disorder and a postoperative disorder9-14.
Patients that survive the operation have greater risk of developing gastroesophageal reflux
disease (GERD), caused by anomalies in the esophageal motility and its resulting delay in the
evacuation of acid of the esophageal lumen.
There was a hypothesis that suggested that motility alteration could contribute to dysphagia
and to the high prevalence of gastroesophageal reflux in these patients15-18. Also, there
were reports of a greater incidence of severe esophagitis with requirement of fundoplication,
which shows a larger failure rate17-18. Esophageal dysmotility has been proved in children
with EA through performance of conventional perfusion manometry.
Lemoine C et al described three motility alteration patterns with HRM in children with
repaired EA. Said study allowed a more precise knowledge of segmental esophageal motility19.
Currently, there are no reports exclusively made about teenagers with repaired EA that
describe segmental esophageal motility with HRM.
n/a
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