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NCT00282854 Clinical Trial

Genetics of Rolandic Epilepsy

Epilepsy Clinical Trial

Official title:
Genetics of Rolandic Epilepsy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00282854
Other study ID # 4727
Secondary ID R01NS047530
Status Completed
Phase
First received
Last updated
Start date January 2005
Est. completion date December 2013

Study information
Verified date August 2011
Source King's College London
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.

Description:

Rolandic epilepsy (RE) is the most common type of childhood epilepsy-affecting more than 50,000 children in the United States-and has a complex genetic inheritance. The seizure prognosis is relatively benign, however, many children with RE also have problems with speech and language, reading, and motor coordination. Symptoms of the disorder overlap with more severe types of epilepsy. The purpose of this study is to find the genes that influence RE and its related traits. Identifying genetic causes for the variants would improve diagnosis and allow for early intervention. Researchers will enroll 1000 children with RE and 3000 controls for participation in the study. The scientists will request medical histories and (salivary) DNA samples from the participants. Participation can be completed by mail and telephone. Results from this study should provide important information regarding diagnosis and prognosis of RE, may be useful in clinical management, and, eventually, may lead to a cure for this and other forms of epilepsy.

Recruitment information / eligibility
Status Completed
Enrollment 1000
Est. completion date December 2013
Est. primary completion date December 2013
Accepts healthy volunteers No
Gender All
Age group 3 Years and older
Eligibility Inclusion: - typical history of focal seizures - EEG centrotemporal sharp waves - age of onset 3-12 years - no previous epilepsy type (febrile seizures OK) - normal development - normal neurological examination - normal MRI/CT (if done) Exclusion: - only history of secondary generalized seizures - atypical history/semiology - history and EEG inconsistent - abnormal EEG background - very early (<3yrs) or late (>12yrs) onset - global neurodevelopmental deficit - deviant neurodevelopment - structural imaging abnormality

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Mailman School of Public Health, Columbia University Medical Center, 722 West 168th St, 6th Floor New York New York

Sponsors (2)
Lead Sponsor Collaborator
King's College London National Institute of Neurological Disorders and Stroke (NINDS)

Country where clinical trial is conducted

United States, 

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