A Clinical Trial for People HIV+ Age > 50 at Risk for Heart Disease

Status Completed

Clinical Trial Summary

This research study is to see whether blood vessel function, an early sign of heart disease, improves in HIV-infected men and women who take telmisartan for 12 weeks. The investigators will be looking at how a blood vessel in the arm, called the brachial artery, changes in response to stress before and after taking telmisartan. To determine how well the blood vessel functions, the investigators will be using an ultrasound machine.

Telmisartan is not an HIV medication. It is an FDA-approved medication designed to treat blood pressure, but has been shown to improve blood vessel function in HIV-negative people with and without high blood pressure. Telmisartan is made by Boehringer Ingelheim, and this trial is sponsored by The Campbell Foundation.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01578772
Study type	Interventional
Source	University of California, Los Angeles
Contact
Status	Completed
Phase	Phase 2
Start date	August 2012
Completion date	March 2013

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02122198` - Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women	N/A
Completed	`NCT04156711` - Remote Ischemic Preconditioning in Patients Undergoing Acute Minor Abdominal Surgery	N/A
Recruiting	`NCT06133634` - Fisetin to Improve Vascular Function in Older Adults	Phase 1/Phase 2
Completed	`NCT05872139` - Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging	N/A
Recruiting	`NCT04558450` - Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)	N/A
Terminated	`NCT03325933` - Resistance Training and Cardiometabolic Health	N/A
Not yet recruiting	`NCT05939934` - Impact of the Mandibular Advancement Device on Sleep Apnea During CPAP Withdrawal	N/A
Completed	`NCT02652975` - Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium	N/A
Recruiting	`NCT02334839` - The Association Between Severity of Hypertensive Disorder During Pregnancy and Endothelial Dysfunction	N/A
Recruiting	`NCT02020044` - Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)	N/A
Completed	`NCT01691404` - Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO)	N/A
Completed	`NCT01775865` - Targeting Inflammation to Treat Cardiovascular Aging	Phase 2
Terminated	`NCT01412216` - The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance	Phase 2
Completed	`NCT01319344` - Effect of Eplerenone on Endothelial Function in Metabolic Syndrome	Phase 3
Completed	`NCT00990730` - Atherosclerosis in Rheumatoid Arthritis	N/A
Completed	`NCT00987974` - Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury	Phase 4
Completed	`NCT00848302` - Endothelial Function in Human Arteries	Early Phase 1
Completed	`NCT00532844` - A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction	Phase 2
Completed	`NCT00376246` - Effect of Ezetimibe on Flow-mediated Brachial Artery Reactivity in Healthy Subjects	Phase 4
Completed	`NCT00775099` - Combustion Derived Air Pollution and Vascular Function	N/A