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Clinical Trial Summary

Design: Prospective randomised cross-over study. Fifty-two eligible patients will be randomised to a treatment time of either 6 hours or 4 hours for a period of 24 weeks and following a washout period of 4 weeks, switch to the alternative treatment time for an additional 24 weeks.

Aims: To examine the feasibility and effect of extended dialysis treatment time, 6 hours thrice weekly, versus the standard, 4 hours thrice weekly, comparing the differences from baseline in outcome measures over a total 12-month period.

Primary outcome measure

1]Serum albumin

Secondary outcome measures Nutritional status

1. Malnutrition-inflammation score

2. Dietary intake

3. Hand-Grip strength

4. Energy expenditure

Quality of life

1. Patient reported quality of life and

2. time to recovery from dialysis

Serum biomarkers

1. BNP

2. Troponin

3. MCP-1

Others 24- hour Ambulatory blood pressure 24-hour accelerometer

Population: Local haemodialysis population of 1200 patients Eligibility: Minimum 90days on haemodialysis treatment Duration: Fifty-six weeks


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Health Services Research


Related Conditions & MeSH terms


NCT number NCT01721421
Study type Interventional
Source Imperial College London
Contact Seema Singh
Phone +44 208 3835249
Email s.singh11@imperial.ac.uk
Status Recruiting
Phase N/A
Start date September 2011
Completion date February 2015

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