Drug Use for Unapproved Schedule Clinical Trial
Official title:
Randomized Phase III Study in EBV Positive Locally Advanced Nasopharyngeal Carcinoma Treated With Concurrent Chemo-radiotherapy With or Without Anti-Viral Drug
PCR-DNA of EBV test is a good prognostic indicator for survival after treatment (report:
Prognostic Impact of Plasma, Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma
Treated using Intensity-Modulated Radiation Therapy.
The chances of the local recurrence or metastasis are higher in the patients at same stage
with positive PCR-DNA of EBV in Nasopharyngeal carcinoma after same treatment.(ref.)
Antiviral drugs have been used to inhibit EBV replication and target viral DNA polymerase are
Foscarnet and phosphonoacetic acid both interact directly with the pyrophosphate-binding site
of the enzyme, where Acyclovir as antiviral drug act at two levels: as competitive
alternative substrates, competing with GTP on the substrate-binding site, and as DNA chain
terminators, by incorporating into the growing DNA chain and blocking its elongation due to
their acyclic structure.
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