Clinical Trials Logo

Clinical Trial Summary

Current efforts to arrest the epidemic of type 2 diabetes mellitus (T2DM) have had limited success. Thus there is an urgent need for effective approaches to prevent the development of T2DM. It is widely accepted that the current epidemic is driven by an increase in global food abundance and reduced food quality, making changes in diet a key determinant of the T2DM epidemic. Dietary factors can affect cardio-metabolic health; among these factors, advanced glycation end-products (AGEs) in food are potential risk factors for insulin resistance and T2DM. AGEs are a heterogeneous group of unavoidable stable bioactive compounds. Endogenous formation of AGEs is a continuous naturally occurring process, and is the result of normal metabolism. However, increased formation of AGEs occurs during ageing and under hyperglycaemic conditions. AGEs are implicated in the development of diabetes and vascular complications. Over the past several decades, methods of food processing have changed and meals now contain excess fat and sugar and are most susceptible for the formation of AGEs. In addition, AGEs in food are highly desirable due to their profound effect on shelf life, sterility, flavour, colour, and thus food consumption. Hence, a substantial portion of AGEs are derived from exogenous sources, particularly food. These exogenous AGEs are potential risk factors for insulin resistance and the development of T2DM. The investigators recently found that dietary AGEs represent a significant source of circulating AGEs, and have similar pathogenic properties compared to their endogenous counterparts including the development of insulin resistance and T2DM. Taken together, dietary AGEs are proposed to play a pivotal role in the development and progression of T2DM and its complications. Reduction of dietary intake of AGEs may therefore be an alternative strategy to reduce the risk of vascular disease and insulin resistance. The investigators therefore hypothesize that dietary restriction of AGEs in overweight individuals improves insulin sensitivity, β-cell function, and vascular function.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03866343
Study type Interventional
Source Maastricht University Medical Center
Contact
Status Completed
Phase N/A
Start date September 7, 2018
Completion date March 3, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT03995979 - Inflammation and Protein Restriction N/A
Recruiting NCT06144905 - Norwegian Microbiota Study in Anorexia Nervosa
Completed NCT00983567 - An Interactive Web-Based Program to Improve Food and Activity Choices of Teens N/A
Enrolling by invitation NCT05057039 - The Study of Gut Microbiota in Hypertensive Patients
Completed NCT04880525 - The Effect of a Weight-Loss Diet in Women Doing Reformer Pilates: A 12-Week Evaluation N/A
Recruiting NCT04733300 - Online Mindfulness-Based College for Young Adults N/A
Completed NCT05472454 - The Ready-to-Eat Meals for Cardiovascular Health Study N/A
Recruiting NCT05394363 - Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Active, not recruiting NCT05607745 - Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study N/A
Completed NCT01475526 - The Value of Our Health N/A
Completed NCT01249508 - Nutrition Labeling Program to Promote Healthy Dietary Patterns N/A
Completed NCT04576260 - Effect of CBT Intervention to Improve Sleep on Wellbeing, Dietary Intake and Food Preference N/A
Completed NCT03949543 - The Timing of Main Meal Consumption Effect on Gut Microbiota and Host N/A
Completed NCT03350568 - Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort N/A
Completed NCT04975529 - Game on Philly: Engaging Underserved Middle School Youth in Out-of- School Time Sports and Nutrition Education N/A
Completed NCT00339677 - Recontacting Participants in the Observing Protein and Energy Nutrition (OPEN) Study: Re-OPEN
Recruiting NCT06152614 - MIND Foods and Aerobic Training in Black Adults With HTN N/A
Completed NCT00870207 - Tu Salud Si Cuenta Worksite: Pilot Intervention Study N/A
Completed NCT02653378 - The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward N/A
Completed NCT00797615 - Project Diabetes: Weight Gain Prevention in Hispanic Girls (GEMAS Study) N/A