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Discovery of Biological Signatures for Cruciferous Vegetable Intake (Single Serving)

Diet, Healthy Clinical Trial

Official title:
Discovery of Biological Signatures for Cruciferous Vegetable Intake: Integration of the Broccoli- and Host-derived Metabolome and the Microbiome

Clinical Trial Summary

The purpose of this project is to study the molecular and metabolic profiles in human plasma, urine and microbiome composition following the consumption of broccoli sprouts.

Clinical Trial Description

The investigators wish to examine metabolic and molecular markers found in blood and in urine after a single dose of sprouts, and evaluate the importance of the gut microbiome on these parameters. Some subjects will receive broccoli sprouts that are grown in deuterium oxide, a commonly used non-toxic, non-radioactive label for vegetables (Tang, Qin et al. 2005), so researchers can identify metabolites in blood and urine that are directly from consumed sprouts. The investigators plan to feed subjects a standardized breakfast and either broccoli sprouts or alfalfa sprouts (control) and look at the presence of metabolites and activity in the blood and urine 3, 6, 24, 48 and 72 hours following intake as well as changes in microbiome composition. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04641026
Study type Interventional
Source Oregon State University
Contact
Status Active, not recruiting
Phase N/A
Start date February 22, 2021
Completion date December 2025
View Details
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