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The Effects of Neprilysin on Glucagon-like Peptide-1 — NEP  

Heart Failure Clinical Trial

Official title:
The Effects of Neprilysin on Glucagon-like Peptide-1

Clinical Trial Summary

In the current study we wish to investigate the effects on glucagon-like peptide-1 (GLP-1) of a neprilysin inhibitor

Clinical Trial Description

Glucagon-like peptide-1(GLP-1) is secreted during a meal and increases glucose induced insulin secretion. The enzyme dipeptidyl peptidase 4(DPP-4) cleaves intact GLP-1 within minutes and DPP-4 inhibitors are therefore used for treatment of diabetic hyperglycemia. A few animal studies have implicated the enzyme neutral endopeptidase 24.11 (24.11) in the degradation of GLP-1 but if this is the case in humans is unknown. We therefore administered a NEP inhibitor, 194mg sacubitril, a DPP-4 inhibitor (sitagliptin 100mg the night before and 100mg 2 hours before), both, or place, to nine healthy men during a standardized meal and measured plasma concentrations of GLP-1 ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03717688
Study type Interventional
Source University of Copenhagen
Contact
Status Completed
Phase Phase 4
Start date May 17, 2018
Completion date May 14, 2019
View Details
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