Clinical Trials Logo

Clinical Trial Summary

The two major types of diabetes are type 1 and type 2 diabetes. Although most patients with type 2 diabetes are older than age 40, type 2 diabetes has been reported with increasing frequency among patients under the age of 20. This form of diabetes has been called type 2 diabetes of youth, abbreviated type 2Y. Little is known about the etiology of type 2Y; however, clinicians believe that it occurs most commonly in obese children of particular ethnic groups. A positive family history appears to be one major risk factor for developing type 2Y diabetes. The individual contribution of ethnicity, obesity, and genetics to type 2Y have yet to be elucidated. There is no consensus regarding treatment with type 2Y diabetes. Observation of our Hispanic patients in the Houston area reveals a large number with type 2Y. The major purpose of this study is to examine the genetic and environmental risk factors such as family history, ethnicity, and obesity in Hispanic children with type 2Y diabetes. SPECIFIC AIMS: 1) To examine the genetic and environmental risk factors and clinical signs associated with type 1 diabetes and type 2 diabetes of youth. 2) To compare the efficacy of the treatment modalities, insulin and oral agents, in type 2Y patients. METHODS: We will undertake a retrospective case study, to include a review of hypothesized risk factors in all the medical records of pediatric diabetes patients seen at University of Texas. We anticipate that approximately 200 patients with type 1 diabetes and 30 patients with type 2Y diabetes will be identified. A Sustacal challenge test will be done in patients with a suspected diagnosis of type 2Y in order to confirm the clinical diagnosis. Parents will be contacted by phone for a detailed pedigree intake. Type 1 and type 2Y patients will be compared for each of the studied features. A retrospective review of diabetes type 2 therapies used in type 2Y patients will be undertaken through further examination of the medical records in order to compare insulin treatment to oral agents. We will also test a subset of the patients for the gene identified in adult Hispanics with type 2 diabetes.


Clinical Trial Description

n/a


Study Design

Observational Model: Defined Population


Related Conditions & MeSH terms


NCT number NCT00004572
Study type Observational
Source National Center for Research Resources (NCRR)
Contact
Status Active, not recruiting
Phase N/A

See also
  Status Clinical Trial Phase
Active, not recruiting NCT02801448 - Clinical Trial With Broccoli Sprout Extract to Patients With Type 2 Diabetes Phase 2
Recruiting NCT01477957 - The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism N/A
Withdrawn NCT01377961 - Effect of Lycopene and Isoflavones on Glucose Metabolism N/A
Completed NCT00754130 - MK-0941 Multiple Dose Study in Japanese Patients With Type 2 Diabetes (MK-0941-011). Phase 1
Completed NCT00006305 - Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes Phase 3
Completed NCT00004983 - Education and Group Support for Diabetic Hispanics N/A
Completed NCT00010751 - Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors Phase 2
Completed NCT02299388 - To Evaluate the Effect of Liraglutide on Ambulatory Blood Pressure-A Pilot Study Phase 4
Completed NCT00550329 - Bioequivalence Study Of Glucotrol XL 2.5 Mg Tablets Phase 1
Completed NCT00172536 - Effects of Exercise Training on Left Ventricular Function in Type 2 Diabetic Patients Post Coronary Artery Bypass Graft N/A
Completed NCT00071422 - Safety and Efficacy of INGAP-Peptide in Patients With Type 2 Diabetes Phase 2
Completed NCT00029848 - Obese Patients With Type 2 Diabetes Phase 3
Completed NCT01608724 - The Efficacy and Safety Study in Patients With Type 2 Diabetes Mellitus Phase 4
Completed NCT01694758 - OPtimal Type 2 dIabetes Management Including Benchmarking and Standard Treatment in CEEMEA N/A
Completed NCT00979368 - Safety Study of BMS-816336 in Healthy Male Subjects Phase 1
Completed NCT00791661 - MK-1006 Single Dose Study in Japanese Type 2 Diabetes Patients (MK-1006-005) Phase 1
Active, not recruiting NCT02088658 - Technology Intensified Diabetes Education Study in African Americans N/A
Completed NCT01105429 - Single Ascending Dose Study of BMS-820132 in Patients With Type 2 Diabetes Phase 1
Completed NCT00701090 - A Study to Test the Safety and Efficacy of Sitagliptin Compared to Glimepiride in Patients With Type 2 Diabetes on a Stable Dose of Metformin (0431-803)(COMPLETED) Phase 3
Completed NCT00952991 - The Effects of LAF237 on Gastric Function in Type 2 Diabetes Phase 3