Depressive Disorder, Treatment-Resistant Clinical Trial
Official title:
Therapeutic Brain Stimulation for Refractory Depression
The purpose of this study is to examine the effects of sub-callosal cingulate (SCC) deep
brain stimulation (DBS) in patients with treatment resistant depression (TRD).
The working hypotheses are that long pulse-width DBS applied to the SCC region will lead to
improvements in TRD patients, and specific neuroimaging biomarkers will correlate with
response to DBS; the functional recovery will be enhanced with concurrent cognitive
behavioural therapy (CBT).
The aim is to collect data on prediction, optimization and augmentation of DBS for TRD and develop tools for DBS surgery. It is a biological pilot study designed to provide informative data for future work. ;
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