Depression Clinical Trial
Official title:
Electrophysiology of Brain Activity During Electrode Implantation in Patients Treated With Deep Brain Stimulation
Primary objective
Demonstrate functional markers derived from electrophysiological signals recorded during
cognitive tests. These markers should make it possible to optimize the targeting procedures
of electrode implantation sites for a better effectiveness of deep brain stimulation therapy.
Research hypotheses
The mechanisms of action of the deep brain stimulation (DBS) involve the modulation of the
activity, locally and on a large scale, of functional cortical-subcortical networks showing
pathological behavior beforehand. The electrophysiological measurements in response to
different tasks make it possible to highlight precise dysfunctions of these neural networks,
in relation with the behavioral and / or motor disorders associated with the pathologies
treated by DBS.
Consequently, we hypothesize that the exploitation of electrophysiological responses during
cognitive or sensorimotor tasks performed during the implantation procedure of stimulation
electrodes in patients treated with DBS will allow :
- To collect fundamental data to understanding the physiological functioning of basal
ganglia in humans ;
- To collect functional markers from the operating room in relation to the symptoms
targeted by the DBS that will help in the choice of implantation site of the stimulation
electrode ;
- Define long-term predictive markers of DBS effects by comparing electrophysiological
effects measured post-operatively and clinical scores under DBS.
n/a
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