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Clinical Trial Summary

The purpose of this study is to investigate changes in functional neural activation during self-regulation tasks before compared to after the Mindfulness Training for Primary Care intervention (see MINDFUL-PC (Phase 3) clinical trial). The study will also look at whether chronic disease self-management action plan initiation and successful engagement of self-report and behavioral self-regulation targets relates to the observed brain activation changes after compared to before the mindfulness intervention.


Clinical Trial Description

The investigators will investigate the effects of MTPC on pre/post changes in neural function with self-regulation target engagement, using self-appraisal, cuff pain and pain anticipation, and interoceptive attention fMRI tasks among primary care patients with an anxiety or depressive disorder. Primary outcome for this study is evaluating the changes in OFC activation during self-criticism blocks within a self-appraisal fMRI task. Secondary outcomes include changes in activation during self-appraisal fMRI task, pain regulation task, and interoceptive attention task, and the relationship of these targets with medical regimen adherence. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03609749
Study type Interventional
Source Cambridge Health Alliance
Contact Zev Schuman-Olivier, MD
Phone 6175916056
Email zschuman@challiance.org
Status Not yet recruiting
Phase N/A
Start date September 5, 2018
Completion date June 30, 2020

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