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Clinical Trial Summary

This study will investigate whether seven days administration of the serotonin receptor subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and neural activity in healthy volunteers, compared to placebo administration. Using an experimental medicine approach, the effects of prucalopride on cognitive biomarkers of antidepressant action will be characterised. In a double-blind design, participants will be randomised to receive seven days administration of either prucalopride (1mg daily) or placebo. All participants will come for a Screening visit, Research Visit One (including an MRI scan) and Research Visit Two (including measures of emotional processing and non-emotional cognition). The primary study hypothesis is that seven-day prucalopride administration will have positive effects on emotional processing and reward sensitivity. A secondary hypothesis is that seven-day prucalopride administration will alter non-emotional cognition. Finally, the study will test the hypothesis that seven day prucalopride administration will alter neural activity during an emotional faces task and a memory task.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03572790
Study type Interventional
Source University of Oxford
Contact Susannah E Murphy, DPhil
Phone 01865 618313
Email susannah.murphy@psych.ox.ac.uk
Status Not yet recruiting
Phase N/A
Start date June 2018
Completion date March 2020

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