Depression Clinical Trial
Official title:
Mechanisms of Mindfulness-Based Interventions (MBIs)
Mindfulness-based Interventions (MBIs) are a family of standardized cognitive and behavioral therapies that focus on cultivating mindfulness-related skills for improving maladaptive cognitive, emotional, and behavioral processes. MBIs have been developed for a wide range of problems, disorders, and populations and are increasingly available in a variety of health settings. This mixed methods study proposes to investigate proposed neurobiological, physiological, psycho-social-behavioral, and cognitive mechanisms by which MBIs may improve health outcomes.
The state of mindfulness can be described as a form of meta-awareness in which attention is
allocated to the present moment of external and internal sensory or mental experience,
without reactivity, and without dwelling on any particular sensory or mental object with
judgement or evaluation. Mindfulness-based Interventions (MBIs) are a family of standardized
cognitive and behavioral therapies that focus on cultivating mindfulness-related skills for
improving maladaptive cognitive, emotional, and behavioral processes.
MBIs have been developed for a wide range of problems, disorders, and populations and are
increasingly available in a variety of health settings. Empirically supported MBIs include
acceptance and commitment therapy (ACT; Hayes, Strosahl, & Wilson, 1999), dialectical
behavior therapy (DBT; Linehan, 1993), mindfulness-based cognitive therapy (MBCT; Segal,
Williams, & Teasdale, 2002), and mindfulness-based stress reduction (MBSR; Kabat-Zinn, 1982,
1990). Variations on these approaches, including integration of mindfulness training into
individual psychotherapy from diverse perspectives, also have been described (Germer, Siegel,
& Fulton, 2005). As the empirical evidence for the efficacy of these interventions continues
to grow, the importance of investigating the mechanisms or processes by which they lead to
beneficial outcomes is increasingly recognized. This mixed methods study proposes to
investigate proposed neurobiological, physiological, psycho-social-behavioral, and cognitive
mechanisms by which MBIs may improve health outcomes. Target (mechanism) engagement is
expected to facilitate identification of individuals who are most likely to benefit (or not)
from MBIs and further develop targeted interventions for optimization of delivery. Although
there are very specific aims and hypotheses to be tested, this preliminary exploratory
investigation will provide feasibility data and allow for refining existing hypotheses for
larger research proposals to be submitted for extramural grant support.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03207828 -
Testing Interventions for Patients With Fibromyalgia and Depression
|
N/A | |
Recruiting |
NCT02783430 -
Evaluation of the Initial Prescription of Ketamine and Milnacipran for Depression in Palliative Care
|
Phase 2/Phase 3 | |
Recruiting |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
N/A | |
Active, not recruiting |
NCT03069417 -
Support for Perinatal Adherence and Depression
|
N/A | |
Active, not recruiting |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
Enrolling by invitation |
NCT03276585 -
Night in Japan Home Sleep Monitoring Study
|
||
Enrolling by invitation |
NCT03275571 -
HIV, Computerized Depression Therapy & Cognition
|
N/A | |
Terminated |
NCT03272555 -
WILD 5 Wellness: A 30-Day Intervention
|
N/A | |
Recruiting |
NCT02543983 -
Neurobiology of Suicide
|
Phase 2 | |
Completed |
NCT03129204 -
Sensation Awareness Focused Training for Spouses
|
N/A | |
Completed |
NCT01198197 -
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A
|
Early Phase 1 | |
Recruiting |
NCT03749278 -
Latina Friends Motivating the Soul (ALMA)
|
N/A | |
Recruiting |
NCT03673397 -
The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression
|
N/A | |
Recruiting |
NCT03537053 -
An Approach to "Move a Little & Often" With Health Conditions
|
N/A | |
Recruiting |
NCT00024635 -
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
|
||
Not yet recruiting |
NCT03645447 -
The Taste-Mood Diagnostic Study
|
N/A | |
Not yet recruiting |
NCT03687450 -
An Evaluation of Changes in Psychological Health to a Yoga Program for Medical Residents
|
N/A | |
Recruiting |
NCT02777112 -
The Effects of E-mental Health Program and Job Coaching on the Risk of Major Depression in Canadian Working Men
|
N/A | |
Recruiting |
NCT02987582 -
A Feasibility Study of an Emotion-Focused Mindfulness Group
|
N/A | |
Recruiting |
NCT02970825 -
Move and Feel Good : Effects of Intensive Physical Training on Brain Plasticity, Cognition and Psychological Well-being.
|
N/A |