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Clinical Trial Summary

This study will evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease.


Clinical Trial Description

The primary purpose of this study is to evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease. This study will also investigate the link between oral and systemic inflammation in patients diagnosed with depression and periodontal disease. Researcher will collect gingival crevicular fluid, plaque, tissue and blood serum samples to evaluate the link between these two diseases. The collection of gingival crevicular fluid, plaque and blood serum is relatively non-invasive, elicits minimal discomfort and does not require use of any anesthesia. The soft tissue sample will be collected as part of an otherwise planned periodontal surgical procedure under local anesthesia. In periodontal therapy (surgical procedures i.e. gum surgery, tooth extraction and or dental implant surgery) there is enough availability of remnant tissue for the collection of samples, which is otherwise discarded. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03553095
Study type Interventional
Source University of Alabama at Birmingham
Contact Maninder Kaur, BDS, MS
Phone 2059344506
Email maninder@uab.edu
Status Not yet recruiting
Phase N/A
Start date July 30, 2018
Completion date August 30, 2019

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