Depression Clinical Trial
Official title:
Learning, Neural Signaling of Cortisol, and Early Adversity in Depression
The stress-related hormone cortisol has been studied in depression for decades. However,
relatively little is known about the role of cortisol in psychological features of
depression. Basic research shows that cortisol modulates brain processes that are highly
relevant to depression (especially the neural substrates of negative biases in learning and
memory formation). However, very few studies have directly examined the effects of cortisol
on neural circuitry of learning in depressed humans. In addition, the effects of cortisol on
the neural substrates of learning differ for males and females. The toll of depression is
especially high in women, who are roughly twice as likely as men to suffer from depression.
Thus, the primary goal of this project is to investigate the effects of cortisol on the
neural circuitry of learning in depressed women.
A secondary goal is to investigate whether early life adversity moderates cortisol's effects
on the neural circuitry of learning. Animal data suggests that early life adversity causes
life-long biases toward learning in threatening conditions associated with elevated
cortisol. In addition, new data from humans suggests that alterations in cortisol
traditionally ascribed to depression may stem in part from early adversity rather than
depression per se. Thus, this study will examine effects of cortisol on the neural circuitry
of learning in depressed and healthy women with and without history of early life adversity.
The study will use pharmacological manipulation of cortisol levels (compared to placebo)
during measurement of brain activity at rest and during memory encoding of emotional and
neutral stimuli. The study will also measure whether cortisol alters the negative biases in
emotional memory often seen in depression. In doing so, the study will examine the role of
cortisol in neural networks associated with emotional learning that are often implicated in
depression.
Medications that target cortisol receptors in the brain may be beneficial in the treatment
of depression. However, this knowledge has yet to inform clinical practice, and mechanisms
of action of these medications are not well understood. This project is significant because
it provides the prerequisite knowledge (and develops a paradigm) that can be used in the
future in the development of more effective targeted intervention strategies.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05777044 -
The Effect of Hatha Yoga on Mental Health
|
N/A | |
Recruiting |
NCT04680611 -
Severe Asthma, MepolizumaB and Affect: SAMBA Study
|
||
Recruiting |
NCT04977232 -
Adjunctive Game Intervention for Anhedonia in MDD Patients
|
N/A | |
Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
Completed |
NCT04512768 -
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
|
N/A | |
Recruiting |
NCT03207828 -
Testing Interventions for Patients With Fibromyalgia and Depression
|
N/A | |
Completed |
NCT04617015 -
Defining and Treating Depression-related Asthma
|
Early Phase 1 | |
Recruiting |
NCT06011681 -
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
|
||
Completed |
NCT04476446 -
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
|
Phase 3 | |
Recruiting |
NCT02783430 -
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
|
Phase 2/Phase 3 | |
Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
Completed |
NCT04598165 -
Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal Support
|
N/A | |
Completed |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
||
Recruiting |
NCT05956912 -
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
|
||
Completed |
NCT05588622 -
Meru Health Program for Cancer Patients With Depression and Anxiety
|
N/A | |
Recruiting |
NCT05234476 -
Behavioral Activation Plus Savoring for University Students
|
N/A | |
Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
Enrolling by invitation |
NCT03276585 -
Night in Japan Home Sleep Monitoring Study
|
||
Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
Terminated |
NCT03275571 -
HIV, Computerized Depression Therapy & Cognition
|
N/A |