Clinical Trials Logo

Clinical Trial Summary

The aim of the current project is to validate PDE4 inhibitors as a target for cognition enhancers (proof-of-concept) using a translational behaviour-EEG approach. The project will demonstrate whether memory, but also attention, information processing or executive function improves with the PDE4 inhibitor roflumilast in healthy humans.

Clinical Trial Description


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

NCT number NCT01433666
Study type Interventional
Source Maastricht University Medical Center
Status Completed
Phase Phase 2
Start date September 2011
Completion date September 2013

See also
  Status Clinical Trial Phase
Completed NCT03357328 - Therapy Light Rooms for Improved Sleep in Dementia Patients N/A
Not yet recruiting NCT03583879 - Using Gait Robotics to Improve Symptoms of Parkinson's Disease N/A
Recruiting NCT02774720 - Centre- Versus Home-based Exercise for MCI and Early Dementia N/A
Recruiting NCT02937883 - Empowerment Intervention for Persons With Young Onset Dementia N/A
Enrolling by invitation NCT02921477 - Study for the Use of TKIs for Treatment of Cognitive Decline Due to Degenerative Dementias Phase 1
Enrolling by invitation NCT03035201 - COcoa Supplement and Multivitamin Outcomes Study for the Mind N/A
Completed NCT02953574 - Daily Sleep Enhancement for Hospitalized People With Dementia Following a Nursing Protocol N/A
Not yet recruiting NCT02845830 - Trajectories of Quality of Life by the Elderly in Early Phase of Dementia N/A
Active, not recruiting NCT02549872 - Dementia Phenotypes in Primary Care, Hospital, and National Mortality Registries N/A
Recruiting NCT02813434 - Cerebral Amyloid Imaging Using Florbetapir (AV-45) for the Etiological Diagnosis of Poststroke Cognitive Impairment and Dementia Phase 3
Recruiting NCT02317523 - Alzheimer's Caregiver Coping: Mental and Physical Health N/A
Recruiting NCT02260167 - Treatment of Alzheimer's and Dementia With the Metabolism, Infections, Nutrition, Drug Elimination (MIND) Protocol Phase 2
Recruiting NCT02260141 - Treating Alzheimer's and Dementia With D-ribose Phase 2
Enrolling by invitation NCT02233530 - IDEA Study Cognitive Stimulation Therapy (CST) Trial in Nigeria N/A
Completed NCT02229474 - IDEA Study Cognitive Stimulation Therapy (CST) Trial in Tanzania N/A
Completed NCT02286791 - Mindful Awareness Program for the Prevention of Dementia: A Randomized Controlled Trial N/A
Completed NCT01441726 - Palliative and End-of-life Care in Advanced Dementia: Evaluation of a Program of Organization of Care in Long-term Care N/A
Completed NCT02262104 - Effects of an Exercise Program for Nursing Home Patients With Dementia N/A
Completed NCT01582919 - Neuroimaging Markers of Alzheimer Disease: a Longitudinal Population Study N/A
Completed NCT01842022 - The Effect of the Glycemic Load of Meals on the Cognition and Mood of Older Adults N/A