Cytomegalovirus Infections Clinical Trial
Official title:
The Relation Between the Maternal Cellular Immune System and Cytomegalovirus Intrauterine Infection
The purpose of this study is to find a correlation between function of cytomegalovirus -specific T cells and the probability for intrauterine transmission.
Fetal infection with CMV is the most common cause of intrauterine infection. Only 40% of
pregnant women with primary CMV transmit the virus to their fetus. Many of these women are
referred to amniocentesis and many elect to terminate pregnancy without knowledge about fetal
infection or damage. Currently it is assumed that transmission is dictated by variety of
factors including maternal and fetal immune system. Efforts to find correlation between
maternal immune system and fetal infection which can be used as a diagnostic marker were
unsuccessful.
Our hypothesis is that there is a correlation between cellular immune response of the mother
to CMV infection and viral transmission to the fetus.
Pregnant women with primary CMV infection (40% of whom are expected to be transmitters)and
with pre-conception immunity will participate in this study.
Blood from these women will be incubated with CMV peptides and T cell activation will be
measured by the secretion of various cytokines.
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