Cystic Fibrosis Clinical Trial
Official title:
Steady-state Pharmacokinetics of Ceftazidime/Avibactam in CF
The purpose of this research study is to characterize the pharmacokinetics of intravenous ceftazidime/avibactam in patients with Cystic Fibrosis.
Cystic fibrosis is a genetic disorder characterized by a chronic cycle of airway infection,
obstruction, and inflammation leading to progressive loss of lung function and eventual
respiratory failure. The principal pathogen is Pseudomonas aeruginosa which is present in the
airways of 70% of adult patients with CF. Of particular concern is the increasing resistance
observed to existing agents.
While ceftazidime has been the mainstay of treatment for many years, its efficacy is limited
by reduced susceptibility. Ceftazidime/avibactam offers a potential advancement in the
management of infections involving P. aeruginosa in CF due to its excellent activity,
penetration into pulmonary secretions, and reduced potential for development of resistance.
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