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Cystic Fibrosis clinical trials

View clinical trials related to Cystic Fibrosis.

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NCT ID: NCT04306939 Suspended - Clinical trials for Rheumatoid Arthritis

Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study

GREAT1
Start date: November 1, 2014
Phase:
Study type: Observational

This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect clinical decision making. The study will evaluate risk factors and co-variants, including genetic variants that are associated with disease progression such as pain, inflammation, organ dysfunction, disability and quality of life.

NCT ID: NCT03756922 Suspended - Cystic Fibrosis Clinical Trials

A DDI Study of FDL169 and FDL176 in Healthy Subjects

Start date: November 27, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

A DDI study to assess the safety, tolerability and pharmacokinetics of both; doses of FDL176 with and without co-administration of FDL169 and doses of FDL169 with and without co-administration of FDL176.

NCT ID: NCT02912637 Suspended - Cystic Fibrosis Clinical Trials

Hyperpolarized Xenon Imaging in Patients With Cystic Fibrosis

Start date: October 2016
Phase:
Study type: Observational

Chronic lung diseases show a gradual onset of irreversible lung damage which can lead to severe breathing problems and/or respiratory failure. Imaging is central to guiding treatment; however, current techniques are either inaccurate or involve exposure to radiation. Recent developments in lung magnetic resonance imaging (MRI) provide promise as a radiation-free alternative. However, conventional MRI cannot directly show changes in distribution of inhaled air or absorption of gas which are important signs of early lung disease. Recently MRI imaging of the inhaled gas contrast agent Xenon has been developed which can provide this important information. This study aims to determine how Xenon MRI can help determine air flow distribution and gas uptake in the lungs. The investigators will also be able to compare the information from patients with that from healthy volunteers. This should give insight into the processes involved in chronic lung diseases and help evaluate disease extent in patients.

NCT ID: NCT00008775 Suspended - Cystic Fibrosis Clinical Trials

Pressure Support Ventilation During CF Exacerbations

Start date: n/a
Phase: N/A
Study type: Interventional

Chest physiotherapy is recognized as a mainstay of cystic fibrosis therapy, and is particularly important during treatment of pulmonary exacerbations. For some patients, especially those with moderate to severe compromise of lung function, this therapy may impose a high demand in the work of breathing and energy expenditure. The goal of this study is to evaluate the effectiveness of adding pressure support ventilation (PSV) during chest physiotherapy sessions in patients with cystic fibrosis with moderate to severe lung function compromise being treated for a pulmonary exacerbation.

NCT ID: NCT00005110 Suspended - Cystic Fibrosis Clinical Trials

A Multi-Centered Study of the Long-Term Effect of Salmeterol and Albuterol in Cystic Fibrosis

Start date: n/a
Phase: N/A
Study type: Interventional

Long term use of bronchodilators in CF is beneficial to the improvement of pulmonary function and symptoms. This study is investigating the long-term benefit of administration of the drug Salmeterol, a bronchodilator. Salmeterol will be compared to albuterol or placebo. The medication will be inhaled twice a day for 6 months.