Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency

CTLA4 Haploinsufficiency Clinical Trial

Official title:
Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency

Status Completed

Clinical Trial Summary

CTLA4 and LRBA deficiencies are rare genetic disorders, recently described, and associated with multiple clinical features. It ranges from recurrent infections, auto-immunity, and organ infiltration with lymphocytes. Neurologic syndroms are described in up to 30% of patients, yet they are poorly defined to date. Early recognition of a specific pattern can be important, given that there is a targeted therapy in this situation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

CTLA4 Haploinsufficiency

Clinical Trial Details

NCT number	NCT05040256
Study type	Observational
Source	University Hospital, Montpellier
Contact
Status	Completed
Phase
Start date	February 1, 2021
Completion date	September 30, 2021

View Details

See also
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	Recruiting	`NCT04377867` - New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies