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Clinical Trial Summary

Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery. Despite the high frequency, associated disability, and cost there are no are no treatment strategies that aim to improve the outcome of this disease complication. The STRIDENT (stricture definition and treatment) studies aim to develop such strategies.


Clinical Trial Description

Prospective randomised controlled study. Patients with Crohn's Disease who have symptomatic inflammatory intestinal strictures will be randomised to receive standard drug therapy (Anti-TNF monotherapy at standard dose) or intensive drug therapy (Intense Anti-TNF dose induction and escalation for continued inflammation in combination with thiopurine) for 12 months. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03220841
Study type Interventional
Source St Vincent's Hospital Melbourne
Contact
Status Active, not recruiting
Phase Phase 4
Start date October 9, 2017
Completion date September 2021

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