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Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes

Critical Illness Clinical Trial

Official title:
Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes

Clinical Trial Summary

This study is designed to study the variations in the microbiome among critically ill patients and the effect of admission to the medical intensive care unit (MICU) at the University of Chicago. Additionally, investigators will examine the downstream clinical effects of dysbiosis in ICU patients and how patients maybe effected long term.

Clinical Trial Description

During this study investigators will longitudinally collect discarded stool biosamples throughout the MICU admission when available. Stool Bio specimens will be recorded/coded and processed by the investigators. Stool Bio specimens will be analyzed for 16sRNA and metabolomics. Surveys will be conducted at study entry, in addition to 6 months and 12 months following discharge. By longitudinally sampling discarded biospecimens from subjects throughout their MICU admission in additionally to describing long term following up. We will be able to correlate changes in the microbiome with clinical data, and follow up surveys to identify factors that may impact the composition of the microbiome and their impact on clinical outcomes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04552834
Study type Observational
Source University of Chicago
Contact
Status Active, not recruiting
Phase
Start date September 15, 2020
Completion date December 1, 2024
View Details
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