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NCT ID: NCT03186768 Recruiting - Hand Disinfection Clinical Trials

Soap on a Rope Trial

Start date: June 12, 2017
Phase: N/A
Study type: Interventional

The soap on a rope behavioral trial is a school-randomized trial to determine if a disruptive cue (the soap on a rope hall pass) can influence hand washing behavior for students in Namwala District, Zambia.

NCT ID: NCT03158844 Recruiting - Hiv Clinical Trials

HIV Care Cascade and Linkage to Antiretroviral Therapy Among Hospitalized Adults in Lusaka, Zambia

COLAH
Start date: May 16, 2017
Phase: N/A
Study type: Observational

The population of inpatients is large in Zambia; however, because of poor linkages between hospitals and community HIV care, there are few data to analyze their engagement in HIV care before and after hospitalization. The goal of the study is to learn more about Zambian adults who are HIV-infected and get hospitalized. The purpose of this study is to gather formative, preliminary data, to be used in future grant applications to improve linkage and engagement in HIV care in Zambia.

NCT ID: NCT03158818 Recruiting - Clinical trials for Hepatocellular Carcinoma

Chronic Hepatitis B Virus Infection in Zambia

HUTCH
Start date: August 23, 2016
Phase: N/A
Study type: Observational

Chronic hepatitis B virus infection is a common condition in Zambia. Among Zambian blood donors, up to 8% are chronically infected with HBV. Despite the burden, awareness of HBV is low in Zambia and the Ministry of Health is in early stages of development of guidelines for HBV screening, treatment, and prevention. The purpose of this clinical cohort study is to characterize the clinical features of chronic HBV infection at UTH and describe treatment and care outcomes. The investigators will enroll 500 adults and follow the cohort for up to 5 years to assess short and long-term viral, serologic, and liver outcomes such as cirrhosis and liver cancer.

NCT ID: NCT03149627 Recruiting - Alcoholic Hepatitis Clinical Trials

Chronic Hepatitis B Virus Clinical Epidemiology in a Representative Sample of Zambian Adults

HEP-ZED
Start date: June 7, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to recruit a random and representative sample of individuals within several Zambian communities for markers of Hepatitis B Virus (HBV) and to characterize chronic HBV infection and indications for treatment.

NCT ID: NCT03141736 Recruiting - Preterm Birth Clinical Trials

Kangaroo Mother Care With Plastic Bag (Trials 1A & 1B)

Start date: May 19, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the combination of Kangaroo Mother Care (KMC) as continuously as possible together with the use of a plastic bag in combination with routine World Health Organization (WHO) thermoregulation care reduces the incidence of moderate (32-36° C) or severe (<32.0° C) hypothermia in preterm infants ≥ 32 to 36 6/7 weeks of gestational age (GA) when compared to KMC as continuously as possible together with routine WHO thermoregulation care.

NCT ID: NCT03141723 Recruiting - Preterm Infant Clinical Trials

Kangaroo Mother Care With Plastic Bag (Trials 2A & 2B)

Start date: May 19, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the combination of Kangaroo Mother Care (KMC) as continuously as possible together with the use of a plastic bag in combination with routine World Health Organization (WHO) thermoregulation care reduces the incidence of moderate (32-36° C) or severe (<32.0° C) hypothermia in term infants ≥ 37 0/7 weeks of gestational age (GA) when compared to KMC as continuously as possible together with routine WHO thermoregulation care.

NCT ID: NCT03134924 Completed - Clinical trials for Vaginosis, Bacterial

Vaginal Practices in Human Immunodeficiency Virus (HIV) Positive Women in Zambia, a Bio-Behavioral Intervention "WASH-2"

Start date: May 3, 2013
Phase: N/A
Study type: Interventional

Intravaginal practices (IVP) (cleansing or introducing products inside the vagina for hygiene, health or to please sexual partners) are common among women with HIV. IVP increase the risk of developing bacterial Vaginosis (BV), the most common genital infection associated with transmission of sexually transmitted infections and HIV. This study tested a pilot intervention to reduce IVP and BV in HIV infected women in Zambia. A total of 128 HIV infected women engaging in IVP were randomized to two conditions: enhanced standard of care (n = 70) and experimental (n = 58). All participants received a brief educational counseling session on discontinuation of IVP, and those with BV, were provided with medical treatment for BV. Women in the experimental condition received an additional group-based, culturally tailored intervention. Participants completed questionnaires assessing sexual risk factors and IVP and were assessed for BV using Nugent criteria at baseline, 6 months and 12 months.

NCT ID: NCT03132285 Active, not recruiting - HIV Prevention Clinical Trials

Safety and Acceptability Study of PrePex Device When Removing the Foreskin Shortly After Placement of Device

Start date: March 11, 2017
Phase: N/A
Study type: Interventional

To assess the safety and acceptability of the non-surgical PrePex device among healthy adult male participants scheduled for voluntary medical male circumcision when removing the foreskin shortly after device placement.

NCT ID: NCT03122223 Not yet recruiting - HIV Infections Clinical Trials

Evaluating the Safety and Immunogenicity of ALVAC-HIV and MF59®-or AS01B-adjuvanted Bivalent Subtype C gp120 in Healthy, HIV-uninfected Adult Participants

HVTN120
Start date: June 5, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

A phase 1/2a clinical trial to evaluate the safety and immunogenicity of ALVAC-HIV (vCP2438) and of MF59®- or AS01B-adjuvanted clade C Env protein, in healthy, HIV-uninfected adult participants

NCT ID: NCT03101592 Recruiting - HIV-1-infection Clinical Trials

INTERVAL: Varying Intervals of ART to Improve Outcomes in HIV

INTERVAL
Start date: May 31, 2017
Phase: N/A
Study type: Interventional

This is an unblinded cluster-randomized study to evaluate the effectiveness of two strategies for scripting/dispensing of antiretroviral therapy (ART) on retention, virologic suppression, and cost compared to the standard of care. The study will be conducted in Malawi and Zambia among approximately 8,200 HIV-1-infected adults (18 years or older) who are stable on ART. Clusters will be randomized to one of three study arms: (1) standard of care (SOC) ART scripting (varies by country, region, clinic, and/or provider), (2) three-month ART scripting, and (3) six-month ART scripting. 30 clusters will be selected for the study, 15 in Malawi and 15 in Zambia, and will be randomized to a study arm.