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NCT ID: NCT03202030 Recruiting - Clinical trials for Fresh Sockets With Buccal Resorption

Immediate Dentoalveolar Restoration Compared to Bio-oss

Start date: January 2016
Phase: N/A
Study type: Interventional

This randomised controlled trial compares the immediate dentoalveolar restoration and bovine demineralised bone in immediate implants placed in fresh sockets with buccal resorption. A total of 34 patients will be included and followed clinically and radiographically for 18 months. Patient centred outcomes will also be evaluated.

NCT ID: NCT03180424 Enrolling by invitation - Functional Status Clinical Trials

Impact on Functional Status in Older Adults Treated With L-Carnitine

Start date: January 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This study evaluates the impact of the treatment with L-Carnitine on the function of adults over 65 years, in conjunction with regular exercise. Simple randomization will be performed, distributing patients in 3 treatment groups, with L-Carnitine or Placebo, and with physical exercise at home or supervised.

NCT ID: NCT02884765 Recruiting - Clinical trials for Bilateral Condylar Fracture of the Mandible

Bilateral Condylar Fractures Registry

Start date: January 2017
Phase: N/A
Study type: Observational [Patient Registry]

Prospective data will be collected in approximately 250 patients sustaining BCFx with or without any additional fracture(s) of the symphysis. Patients will be followed according to the standard (routine) at approximately 6 weeks and 3 months after the treatment. Data collection will include fracture details (i.e. classification, mechanism of injury), treatment details, functional and patient-reported outcomes, and anticipated or procedure-related adverse events (i.e. complications).

NCT ID: NCT02789540 Completed - Clinical trials for Stable COPD Patients

Latin American Study of 24-hs Symptoms in Chronic Obstructive Pulmonary Disease (COPD) Patients; LASSYC Study

Start date: June 10, 2016
Phase: N/A
Study type: Observational

This is a multi-country, multicentre, observational prospective data collection cross sectional study of patients with stable COPD in Latin America. Primary objective is to assess and characterize COPD symptoms over a period of 24 hours, by collecting information about the respiratory symptoms experienced at different times of the day and night-time in patients with stable COPD under real clinical practice conditions. Correlation between each of these symptoms and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification, adherence to respiratory treatment, level of dyspnea, disease severity, comorbidities and physical activity as well direct costs will be done as secondary objectives. Study population are patients of 40 years and older, smokers or ex smokers of >= 10 pack/years with previous COPD diagnosis, attending outpatient specialists consults in Argentina, Chile, Colombia, Uruguay, Costa Rica, Guatemala and Mexico. Sample size is targeted to 900 enroled patients in order to ensure 860 patients to achieve statistical power to primary objective.

NCT ID: NCT02765503 Recruiting - Clinical trials for Squamous Cell Carcinoma of the Head and Neck

Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck: The HYPNO Trial

Start date: March 2014
Phase: Phase 3
Study type: Interventional

The aim of the study is to test whether a resource-sparing 4-week, 20-fraction course of accelerated hypofractionated radiotherapy is non-inferior to accelerated radiotherapy delivering 33 fractions over 5.5 weeks in the treatment of patients with Stage I-IV squamous cell carcinoma of the pharynx, larynx and oral cavity with the exception of paranasal sinus, nasopharyngeal and stage I-II glottic carcinomas.

NCT ID: NCT02730052 Not yet recruiting - Hypertension Clinical Trials

Telemonitoring of Uncontrolled Hypertension

Start date: June 2016
Phase: Phase 4
Study type: Interventional

The proportion of hypertensive patients achieving adequate blood pressure control meeting guideline targets remains low. Of those patients on blood pressure lowering drugs, only 50% reach control. Objectives: 1. Test the feasibility of telemonitoring of blood pressure in uncontrolled hypertensive patients. 2. Investigate whether telemonitoring enabled self-measurement of blood pressure leads to faster blood pressure control than self-measurement without telemonitoring. 3. Secondary endpoints include adverse effects, assessment of quality of life, adherence, a log of technical problems, and cost-effectiveness. Methods: Randomised parallel-group study consisting of 4 stages. - Screening to check for eligibility. - Randomisation in a 1:1 proportion to control or experimental arm: In the control arm, doctors will receive reports on the self-measured blood pressure based on diary cards; in the experimental group, doctors will receive weekly reports via telemonitoring. - Treatment period: Doctors will adjust treatment according to the present guidelines of Hypertension. Blood pressure control is a home blood pressure below 135 mm Hg systolic and 85 mm Hg diastolic. Once blood pressure control is achieved the treatment period ends. - Late follow-up: Assessment of blood pressure control at home 3 months after completion of the treatment period by means of telemonitoring. Sample size: 120 patients per group. Patients: recruited at clinics from Uruguay and Argentina. Main Inclusion Criteria: - Women and men, age range 20 to 80 years. - Uncontrolled hypertension and new diagnosed hypertension with a self-measured blood pressure at home of 135 mm Hg systolic and/or 85 mm Hg diastolic or more; - Patients should be willing to accept adherence checking during follow-up and sign an informed written consent. Exclusion Criteria - Patients emotionally or intellectually not capable of measuring their blood pressure at home; - A clinical or social context, which is suboptimal for the self-measurement of blood pressure; - Pregnancy; - Alcohol or substance abuse or psychiatric illnesses; - Participation in another study. Expected outcomes: blood pressure control will be achieved faster in the telemonitoring group.

NCT ID: NCT02600624 Recruiting - Clinical trials for Fetal Alcohol Syndrome

Prenatal Alcohol Biomarker Study in Uruguay

Start date: August 18, 2016
Phase: N/A
Study type: Observational

The purpose of this study is to examine the association between maternal alcohol use and newborn phosphatidylethanol (PEth) levels in their newborn.

NCT ID: NCT02570737 Enrolling by invitation - Clinical trials for Pulmonary Hypertension

Latin American Pulmonary Hypertension Registry

Start date: April 2014
Phase: N/A
Study type: Observational [Patient Registry]

The RELAHP registry is a Latin-American multinational, multicenter, prospective observational registry-type cohort study, which pretends to identify clinical characteristics, clinical course, management and outcome of all forms of pulmonary hypertension (PH). All consecutively consented patients newly diagnosed with WHO Group I-V PH according to specific hemodynamic criteria on right heart catheterization at the participating centers will be enrolled. Patients will be followed six-monthly for a minimum of five years from the time of enrollment.

NCT ID: NCT02563054 Completed - Gastric Cancer Clinical Trials

A Study of Capecitabine (Xeloda) in Participants With Advanced or Metastatic Gastric Cancer

Start date: April 2003
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of oral capecitabine (Xeloda) versus 5-fluorouracil (5-FU), in combination with intravenous (IV) cisplatin, in participants with advanced and/or metastatic gastric cancer. The anticipated time on study treatment is at least 6 weeks and continued up to disease progression, and the target sample size is 300 individuals.

NCT ID: NCT02535026 Completed - Breast Cancer Clinical Trials

An Observational Study on HER2 Status of Breast Invasive Carcinoma in Latin American Participants

Start date: July 2011
Phase: N/A
Study type: Observational

This is a descriptive, prospective, observational and epidemiological study on participants recently diagnosed with breast cancer to evaluate the human epidermal growth factor receptor 2 (HER2) status by immunohistochemistry (IHC) and silver in-situ hybridization (SISH) procedures.