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NCT ID: NCT03397420 Recruiting - HIV Infections Clinical Trials

Family-centered HIV Care, Viral Suppression and Retention in HIV-positive Children, Swaziland

Start date: September 13, 2017
Phase: N/A
Study type: Interventional

The study will evaluate the effect of implementing a family-centered care (FAM-CARE) program (where all HIV-positive family members are seen together as a unit and receive care together) on viral suppression and retention in HIV-positive children <15 years through enrollment of a prospective cohort of 660 HIV-positive children and their caregivers at sites that were randomized to either implement the family-care program (intervention sites) or continue the current standard of care (control sites).

NCT ID: NCT03254550 Recruiting - Clinical trials for HIV Negative People Identified at Substantial Risk for HIV Infection

PrEP Demonstration Study in Swaziland

Start date: August 1, 2017
Phase: N/A
Study type: Observational

An 18 month observation cohort study with the overall aim to assess the operationalization of oral Pre-exposure prophylaxis (PrEP) in Swaziland as an additional HIV combination prevention method among population groups and individuals at high risk of HIV infection.

NCT ID: NCT03164564 Recruiting - HIV Infections Clinical Trials

Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

Start date: November 7, 2017
Phase: Phase 3
Study type: Interventional

This study will evaluate the safety and efficacy of the long-acting injectable agent cabotegravir (CAB LA) compared to daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for pre-exposure prophylaxis (PrEP) in HIV-uninfected women.

NCT ID: NCT02969161 Completed - Clinical trials for HIV (Human Immunodeficiency Virus)

Safe Generations Plus: Swaziland PMTCT LTF Study

Start date: March 2016
Phase: N/A
Study type: Observational

This study is to understand how to improve retention in care and treatment services to HIV positive pregnant women and their babies in Swaziland. The investigators will evaluate outcomes of patients who are lost-to-follow-up (LTF) under a new approach for prevention of mother-to-child (PMTCT) called Option B+, where all HIV positive pregnant women initiate lifelong antiretroviral therapy (ART) regardless of their disease stage. The goal is to understand the outcomes of patients who are LTF from care, and the reasons for disengagement from care in the context of PMTCT in order to inform efforts to improve retention in care among patients under Option B+.

NCT ID: NCT02909218 Completed - HIV/AIDS Clinical Trials

MaxART: Early Access to ART for All in Swaziland

Start date: September 1, 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility, acceptability, clinical outcomes, affordability, and scalability of offering early antiretroviral treatment to all HIV-positive individuals in Swaziland's government-managed health system.

NCT ID: NCT02550067 Completed - HIV Clinical Trials

The Evidence for Contraceptive Options and HIV Outcomes Trial

Start date: December 14, 2015
Phase: N/A
Study type: Interventional

The ECHO Study is an open-label randomized clinical trial that will compare three highly effective, reversible methods of contraception (including a non-hormonal method) to evaluate whether there is a link between use of any of these methods and increased risk of acquiring HIV infection. A randomized clinical trial among about 7,800 women in four countries, ECHO will deliver evidence to support and guide individual, policy and programmatic decisions on contraception for women at risk of acquiring HIV infection.

NCT ID: NCT02410434 Completed - Social Stigma Clinical Trials

Reducing Lesbian, Gay , Bisexual and Transgender (LGBT) Stigma in Swaziland and Lesotho

Start date: February 2015
Phase: N/A
Study type: Interventional

The specific objectives of this study are reduce stigma towards lesbian, gay, bisexual, and transgender persons in Swaziland and Lesotho, using performance ethnography at community roundtables.

NCT ID: NCT02315690 Completed - Malaria Clinical Trials

Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland

Start date: September 2015
Phase: Phase 3
Study type: Interventional

This is a cluster randomised controlled trial comparing the impact of two community based malaria interventions: reactive case detection (RACD) vs reactive targeted presumptive treatment (focal mass drug administration, fMDA) on the incidence of malaria in Swaziland.

NCT ID: NCT01971710 Completed - HIV Clinical Trials

Advancing Community Level Action for Improving MCH/PMTCT

Start date: April 2013
Phase: N/A
Study type: Interventional

The goal of the ACCLAIM (Advancing Community-Level Action for Improving MCH/PMTCT) project is to increase community demand for, uptake of, and retention in Maternal and Child Health (MCH) and/Prevention of Mother-to-child transmission of HIV (PMTCT) services to improve country progress toward elimination of pediatric HIV/AIDS.

NCT ID: NCT01904994 Active, not recruiting - Clinical trials for HIV (Human Immunodeficiency Virus)

Link4Health: A Combination Strategy for Linkage and Retention, Swaziland

Start date: August 2013
Phase: N/A
Study type: Interventional

Despite increased HIV (Human Immunodeficiency Virus) infection testing in Africa, many patients never enroll in subsequent HIV care after testing or remain in care after an initial enrollment. This study's aim is to improve linkage to HIV care and retention in HIV care through the use of feasible, evidence-based, and practical interventions. The study takes place in Swaziland, the country with the highest HIV prevalence (24%) in sub-Saharan Africa. The study will randomize groups of HIV testing sites and affiliated clinics to either standard of care or a combined intervention strategy (CIS) which consists of point-of care CD4 (cluster differentiation 4 (CD4)) testing at time of HIV testing, fast-track HIV medications for those who are eligible for treatment,mobile phone appointment reminders, care bags filled with health prevention materials, and financial incentives. The study outcomes are linkage to and retention in care as well as cost effectiveness, feasibility of interventions, and patient acceptability of interventions.