Clinical Trials Logo

Filter by:
NCT ID: NCT03254550 Recruiting - Clinical trials for HIV Negative People Identified at Substantial Risk for HIV Infection

PrEP Demonstration Study in Swaziland

Start date: August 1, 2017
Phase: N/A
Study type: Observational

An 18 month observation cohort study with the overall aim to assess the operationalization of oral Pre-exposure prophylaxis (PrEP) in Swaziland as an additional HIV combination prevention method among population groups and individuals at high risk of HIV infection.

NCT ID: NCT02969161 Enrolling by invitation - Clinical trials for HIV (Human Immunodeficiency Virus)

Safe Generations Plus: Swaziland PMTCT LTF Study

SG+
Start date: March 2016
Phase: N/A
Study type: Observational

This study is to understand how to improve retention in care and treatment services to HIV positive pregnant women and their babies in Swaziland. The investigators will evaluate outcomes of patients who are lost-to-follow-up (LTF) under a new approach for prevention of mother-to-child (PMTCT) called Option B+, where all HIV positive pregnant women initiate lifelong antiretroviral therapy (ART) regardless of their disease stage. The goal is to understand the outcomes of patients who are LTF from care, and the reasons for disengagement from care in the context of PMTCT in order to inform efforts to improve retention in care among patients under Option B+.

NCT ID: NCT02909218 Recruiting - HIV/AIDS Clinical Trials

MaxART: Early Access to ART for All in Swaziland

MaxART
Start date: September 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility, acceptability, clinical outcomes, affordability, and scalability of offering early antiretroviral treatment to all HIV-positive individuals in Swaziland's government-managed health system.

NCT ID: NCT02550067 Recruiting - HIV Clinical Trials

The Evidence for Contraceptive Options and HIV Outcomes Trial

ECHO
Start date: November 2015
Phase: N/A
Study type: Interventional

The ECHO Study is an open-label randomized clinical trial that will compare three highly effective, reversible methods of contraception (including a non-hormonal method) to evaluate whether there is a link between use of any of these methods and increased risk of acquiring HIV infection. A randomized clinical trial among about 7,800 women in four countries, ECHO will deliver evidence to support and guide individual, policy and programmatic decisions on contraception for women at risk of acquiring HIV infection.

NCT ID: NCT02410434 Completed - Social Stigma Clinical Trials

Reducing Lesbian, Gay , Bisexual and Transgender (LGBT) Stigma in Swaziland and Lesotho

Start date: February 2015
Phase: N/A
Study type: Interventional

The specific objectives of this study are reduce stigma towards lesbian, gay, bisexual, and transgender persons in Swaziland and Lesotho, using performance ethnography at community roundtables.

NCT ID: NCT02315690 Recruiting - Malaria Clinical Trials

Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland

fMDA
Start date: September 2015
Phase: Phase 3
Study type: Interventional

This is a cluster randomised controlled trial comparing the impact of two community based malaria interventions: reactive case detection (RACD) vs reactive targeted presumptive treatment (focal mass drug administration, fMDA) on the incidence of malaria in Swaziland.

NCT ID: NCT01971710 Completed - HIV Clinical Trials

Advancing Community Level Action for Improving MCH/PMTCT

ACCLAIM
Start date: April 2013
Phase: N/A
Study type: Interventional

The goal of the ACCLAIM (Advancing Community-Level Action for Improving MCH/PMTCT) project is to increase community demand for, uptake of, and retention in Maternal and Child Health (MCH) and/Prevention of Mother-to-child transmission of HIV (PMTCT) services to improve country progress toward elimination of pediatric HIV/AIDS.

NCT ID: NCT01904994 Active, not recruiting - Clinical trials for HIV (Human Immunodeficiency Virus)

Link4Health: A Combination Strategy for Linkage and Retention, Swaziland

L4H
Start date: August 2013
Phase: N/A
Study type: Interventional

Despite increased HIV (Human Immunodeficiency Virus) infection testing in Africa, many patients never enroll in subsequent HIV care after testing or remain in care after an initial enrollment. This study's aim is to improve linkage to HIV care and retention in HIV care through the use of feasible, evidence-based, and practical interventions. The study takes place in Swaziland, the country with the highest HIV prevalence (24%) in sub-Saharan Africa. The study will randomize groups of HIV testing sites and affiliated clinics to either standard of care or a combined intervention strategy (CIS) which consists of point-of care CD4 (cluster differentiation 4 (CD4)) testing at time of HIV testing, fast-track HIV medications for those who are eligible for treatment,mobile phone appointment reminders, care bags filled with health prevention materials, and financial incentives. The study outcomes are linkage to and retention in care as well as cost effectiveness, feasibility of interventions, and patient acceptability of interventions.

NCT ID: NCT01891799 Active, not recruiting - HIV/AIDS Clinical Trials

Swaziland Safe Generations

Start date: August 2013
Phase: N/A
Study type: Observational

The purpose of this study is to understand how best to provide care and treatment services to human immunodeficiency virus (HIV) positive pregnant women and their babies in Swaziland. The study is designed to evaluate a new approach for Preventing Mother-to-Child Transmission (PMTCT)where all HIV positive pregnant women initiate lifelong triple antiretroviral (ARV) therapy regardless of their disease stage. The goal is to prevent delays in women accessing treatment for their own health and ensure that women and their children remain in care. This study will compare this new approach to PMTCT, known as Option B+, to Option A, which is the current standard of care for PMTCT in Swaziland. The study will be conducted at 10 health facilities in the Manzini and Lubombo regions in Swaziland. The study has three components: the main component is a PMTCT Options Evaluation where data from medical records will be abstracted on all HIV positive pregnant women attending antenatal services at the 10 selected study facilities; data will be abstracted on their HIV exposed infants as well. Other components of the study include a PMTCT Options Acceptability Evaluation using semi-structured questionnaires with PMTCT clients and health care workers (HCWs) as well as a cost effectiveness evaluation comparing costs under conditions of Option A and Option B+.

NCT ID: NCT01694862 Completed - HIV Clinical Trials

Benefits and Costs of Integrating Sexual-Reproductive Health and HIV Services in Kenya and Swaziland

Integra
Start date: January 2009
Phase: N/A
Study type: Interventional

The overarching aim of the Integra Initiative is to strengthen the evidence base on the impact of integrating family planning (FP), postnatal care (PNC) and HIV services in sub-Saharan Africa. Specifically, in the study the investigators aim to test the following hypotheses: the provision of integrated services, compared to separate services, will: 1. lead to increased uptake of a range of SRH services . 2. attract a greater number and diversity of clients. 3. lead to increased quality of a range of SRH services 4. lead to healthier sexual and reproductive behavior. 5. lead to reduced stigma at health facilities. 6. lead to the more efficient use of resources, with a lower unit cost of provision of key services. For the purposes of this study integration is defined as offering clients both HIV and postnatal care (PNC) or HIV and family planning (FP) services in the same visit. To better understand how services can be integrated in different countries this study focuses on two key models of integration in Kenya and Swaziland. - The first model focuses on integration of FP and HIV services (integrated FP model) and entails performing HIV testing, STI screening and management, cervical cancer screening, condom promotion within FP consultations, as well as active referral to antiretroviral (ART) units for HIV-positive clients. The FP model will be evaluated in Kenya only. - The second model focuses on integration of PNC and HIV services (integrated PNC model) and will be implemented in both Kenya and Swaziland. The model focuses on the provision of PNC services to mother and baby, FP services, repeat HIV testing for mother, HIV testing for infant and referral to HIV services for HIV positive mothers and infants, as well as referrals for clients requiring other additional services.