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NCT ID: NCT04813159 Recruiting - STEMI Clinical Trials

Remote Ischaemic Conditioning in STEMI Patients in Sub-Saharan AFRICA

RIC-AFRICA
Start date: January 12, 2022
Phase: N/A
Study type: Interventional

The RIC-AFRICA trial is a multi-centre, sham-controlled, double-blinded, randomised controlled trial (RCT) involving 1200 ST-segment elevation myocardial infarction (STEMI) patients presenting within ≤ 24 hours of myocardial infarction (MI) onset, across approximately 20 sites in four sub-Saharan African countries (South Africa, Kenya, Sudan and Uganda). Patients presenting with STEMI and deemed ineligible for the RIC AFRICA RCT because they present >24 hours from MI onset but less than 72 hours, will be recruited into the observational arm of the study with the same endpoints as the trial. The purpose of the RCT is to determine whether Remote Ischaemic Conditioning (RIC) can reduce the rates of all-cause death and early post-myocardial heart failure at 30-days in STEMI patients treated predominantly with thrombolytic therapy.

NCT ID: NCT04475471 Recruiting - COVID-19 Clinical Trials

WORLD HEART FEDERATION (WHF) COVID-19 and Cardiovascular Disease Survey

WHF
Start date: September 1, 2020
Phase:
Study type: Observational

A global study for a better understanding of the cardiovascular conditions that increase the risk of developing severe COVID-19, and a better characterization of cardiovascular complications in hospitalized patients with COVID-19.

NCT ID: NCT04191213 Recruiting - Clinical trials for Sickle Cell Anemia in Children

Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients

GA&SCA
Start date: February 15, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

To study the efficacy of Gum Arabic as an anti-oxidant, anti-inflammatory and Fetal Hemoglobin-inducing agent among Sickle Cell Disease children. Half of participants will receive Gum Arabic and the other half will receive placebo

NCT ID: NCT03789006 Recruiting - Clinical trials for Kidney Transplant Rejection

Antithymocyte Globulin and Azathioprine Versus Basiliximab and Mycophenolate Mofetil in Living Donor Kidney Transplantation

Start date: March 21, 2018
Phase: Phase 4
Study type: Interventional

Kidney transplantation is the best available treatment option for patients with end stage renal disease. However, kidney transplantation requires life-long use of immunosuppressive medication. Because of the high cost of these medications we need to carefully evaluate the cost-effectiveness of each drug regimen, especially in low-middle income countries. The objective of this clinical trial is to compare the efficiency and cost of two immunosuppressive protocols after living donor kidney transplantation: (1) antithymocyte globulin, tacrolimus, azathioprine and prednisolone versus (2) basiliximab, tacrolimus, mycophenolate mofetil and prednisolone.

NCT ID: NCT03399955 Recruiting - Clinical trials for PKDL - Post-Kala-Azar Dermal Leishmanioid

Short Course Regimens for Treatment of PKDL (Sudan)

Start date: May 9, 2018
Phase: Phase 2
Study type: Interventional

This is an open label, randomized non comparative phase II clinical trial conducted on parallel groups, to assess the safety and efficacy of the combination of Paromomycin (20 mg/kg/d) IM for 14 days and Miltefosine (allometric dosing) oral for 42 days, and a combination of AmBisome® (20 mg/kg total dose) IV over 7 days and Miltefosine oral for 28 days (allometric dosing) for the treatment of PKDL patients in Sudan.

NCT ID: NCT03268733 Recruiting - Clinical trials for Polycystic Ovary Syndrome

The Effects of Folic Acid on Sudanese Women With Polycystic Ovary Syndrome

FolicacidPCOS
Start date: September 1, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

An open clinical trial

NCT ID: NCT03138044 Recruiting - Clinical trials for Hepatocellular Carcinoma

Combined Ipsilateral Liver Lobe Devascularization and Alcohol Treatment of the Large Hepatocellular Carcinoma

Start date: May 20, 2017
Phase: N/A
Study type: Interventional

Assessment of the long-term outcome of combined ipsilateral liver lobe devascularization (ILAD) and alcohol injection of the large hepatocellular carcinoma (HCC): single center non-randomized trial.

NCT ID: NCT03129685 Recruiting - Clinical trials for Hepatocellular Carcinoma

Ipsilateral Liver Lobe Devascularization of the Large Hepatocellular Carcinoma

NRU
Start date: May 20, 2017
Phase: N/A
Study type: Interventional

Assessment of short-term outcomes of ipsilateral lobe arterial devascularization of the large hepatocellular carcinoma: single center non-randomized trial.

NCT ID: NCT03086226 Recruiting - Mycetoma Clinical Trials

Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan

Start date: April 30, 2017
Phase: Phase 2
Study type: Interventional

This study is a single-center, comparative, randomized, double-blind, parallel-group, active-controlled, clinical superiority trial of Fosravuconazole versus Itraconazole combined with surgery in subjects with eumycetoma in Sudan. There will be three arms in this study: The first arm will be Fosravuconazole 300 mg weekly, the second arm will have Fosravuconazole 200 mg weekly and the control arm is the standard treatment using itraconazole 400mg daily. At 3 months time-point, interim analysis will be done and one of the study arms will be dropped according to the drop-the-loser design, based on efficacy or toxicity.

NCT ID: NCT02804581 Recruiting - Clinical trials for Rheumatoid Arthritis

Gum Arabic as Immunomodulator In Rheumatoid Arthritis Patients

Start date: June 2016
Phase: Phase 2
Study type: Interventional

Gum Arabic (GA) rich dietary fiber it is a water-soluble dietary fiber derived from the dried gummy exudates of the stems and branches of Acacia senegal, GA found to have strong immuno modulator in vitro where it increased IL10 production showing strong anti-inflammatory effects (19). The aim of this study is to determine the role of gum Arabic in immunomodulation among patients with rheumatoid arthritis.