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NCT ID: NCT03368300 Recruiting - Clinical trials for Atypical Parkinsonism

Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

Start date: August 3, 2012
Phase: N/A
Study type: Interventional

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.

NCT ID: NCT03368261 Completed - Sickle Cell Disease Clinical Trials

Epidemiology and Pathophysiological Mechanisms of HTAP in SS and SC Children in Martinique and Guadeloupe.

Start date: January 11, 2010
Phase: N/A
Study type: Interventional

pulmonary arterial hypertension (PAH) has been reported with a prevalence of approximately 30% in adult sickle cell disease (SCD) patients, with an increased mortality in SCD patients with PAH, compared with those without PAH. The identification of several hemolysis biomarkers such as lactate dehydrogenase, bilirubin, reticulocytes or hemoglobin level, has clearly documented a link between hemolysis and PAH. However, other physiopathological mechanisms may be involved to explain PAH in these patients, such as pulmonary thromboembolism, pulmonary fibrosis or left heart diastolic and / or systolic dysfunction. The investigators suggest studying HTAP in patient's presenting the most frequent both drepanocytic syndromes, SS and SC and homogeneous in their medical coverage and the association between HTAP risk and specific SCD complications.

NCT ID: NCT03367650 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies

Start date: May 13, 2014
Phase: N/A
Study type: Interventional

The diagnosis and the follow-up of the patients reached of SLA is centralized, since a few years, at the the Caribbean Reference center of the rare neurological diseases (CERCA labélisé in 2006) in Martinique and at the Unity of coverage of the neuromuscular Diseases, SLA and the rare neurological diseases (create in 2010) in Guadeloupe. Several phenotypic characteristics seemed to us to take out again data collected during the follow-up of the patients (26 in Guadeloupe, since the creation of the unity) in particular patients' high proportion of exceptionally long evolution (more than 10 years). Besides, we diagnosed several cases (10 cases in Guadeloupe since 2000) of association SLA- Parkinsonien Syndrome. This association, considered as exceptional could establish a particular phenotypic entity which we would like to describe. We are interested also originally geographical of the patients, with the hypothesis that he could exist in the Antilles one or several geographical isolates of the disease allowing to lead a étiologique investigation in search of a possible genetic or environmental cause.

NCT ID: NCT03328338 Not yet recruiting - Cardiac Amyloidosis Clinical Trials

Mitochondrial Function in Transthyretin Amyloidosis

Start date: January 2018
Phase: N/A
Study type: Observational

Hereditary (familial) amyloidosis arising from the misfolding of a mutated or variant transthyretin, is the most frequent form of amyloid cardiomyopathy in the Caribbean basin. Affected organs invariably harbor extracellular amyloid deposits in the myocardium. Circulating or pre-fibrillar amyloidogenic proteins are implicated in the disruption of cell function. Our aim is to demonstrate that transthyretin mediated amyloid disease alter the mitochondrial function of cardiac cells.

NCT ID: NCT03322319 Completed - Clinical trials for Left Ventricular Hypertrophy

Frequency of Cardiac Amyloidosis in the Caribbean's. (TEAM Amylose)

Start date: September 23, 2013
Phase: N/A
Study type: Interventional

The frequency of cardiac amyloidosis among patients presenting with a so-called left ventricular hypertrophy remains unknown. This problem is especially relevant in the Caribbean's, where an amyloidosis-prone mutation of transthyretin gene might be frequent.

NCT ID: NCT03306251 Recruiting - Clinical trials for Mother to Child Transmission of HIV

National Cohort of Children Born to HIV-positive Mothers

Start date: June 2005
Phase: N/A
Study type: Observational

The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.

NCT ID: NCT02912546 Recruiting - Brain Ischemia Clinical Trials

Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study

Start date: October 2016
Phase: N/A
Study type: Interventional

Postural changes are commonly used as therapeutic maneuver to enhance or reduce cerebral perfusion. For instance, in acute stroke, the patient can be positioned in head down tilt position so as to increase perfusion of cerebral tissues perfusion. In During stroke and in hypertensive patients and during stroke, varying degrees a various loss of cerebral autoregulation is loss are usually observed. The aim of this study is to assess cerebral perfusion with ASL perfusion in human subjects in different conditions: healthy, hypertensive and stroke.

NCT ID: NCT02704312 Recruiting - Breast Cancer Clinical Trials

Dosimetric Comparison of Doses in Both Positions (Prone and Decubitus) for Patient With Breast Cancer

Start date: November 30, 2015
Phase: N/A
Study type: Interventional

Compare dosimeters in both positions (prone and decubitus) for each patient

NCT ID: NCT02562482 Active, not recruiting - Clinical trials for Chikungunya Virus Infection

Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults

Start date: October 2015
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety and immunogenicity of a 2 injection vaccine Chikungunya virus (CHIKV) and virus like particle vaccine (CHIKV VLP) in healthy adults.

NCT ID: NCT02516579 Active, not recruiting - Sickle Cell Disease Clinical Trials

European Sickle Cell Disease Cohort - Hydroxyurea

Start date: January 2009
Phase: N/A
Study type: Observational

In the context of the Risk Management Plan (RMP), as requested from Addmedica by the EMEA, to collect information about long-term safety of Siklos® (hydroxycarbamide) when used in current practices for the prevention of symptomatic vaso-occlusive complications in patients with Sickle Cell Disease.