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NCT ID: NCT03656640 Recruiting - Autoimmune Diseases Clinical Trials

Trial Assessing Safety and Efficacy of Gammanorm® in Autoimmune Diseases

Start date: November 23, 2016
Phase:
Study type: Observational

This observational trial assesses the safety and efficacy of Gammanorm® in autoimmune diseases.

NCT ID: NCT03603457 Recruiting - Multiple Sclerosis Clinical Trials

OFSEP High Definition Cohort

OFSEP HD
Start date: July 10, 2018
Phase:
Study type: Observational [Patient Registry]

For neurologists and patients, it appears that one major unmet need, beside of course a cure to multiple sclerosis (MS), is to better appreciate the causal factors of disease progression, and even to obtain reliable predictive tools that could apply on the individual level and at different key moments in the disease course. The overarching objective of the OFSEP-HD cohort is to determine prognostic factors of the evolution of disability in MS in real life, looking at disease characteristics, care practices potentially modifying the evolution of the disease since MS clinical onset and along specific post-onset landmarks. This general framework leads to study 3 specific research objectives: 1. To identify determinants (socio-demographic characteristics, clinical characteristics, health related quality of life (QoL), changes in classification, and biomarkers) for the progression of MS disease and its consequences; 2. To study the effectiveness of treatments in real life; 3. To merge both determinants and treatments for creating patient-centered prognostic tools for identifying specific subgroups of patients and helping making decision to start, maintain or adapt care management. To achieve these objectives, the OFSEP (The French multiple sclerosis registry) infrastructure, managed under a quality insurance system, offers a unique opportunity for the first time in France to create a large cohort of MS cases, providing high-definition and sequential multimodal data.

NCT ID: NCT03584711 Recruiting - Clinical trials for Metastatic Colorectal Cancer

FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

OPTIPRIME
Start date: April 26, 2018
Phase: Phase 2
Study type: Interventional

Single-arm, multi-centre phase II study The primary objective is to evaluate the time to failure of the strategy.

NCT ID: NCT03580070 Recruiting - Immunotherapy Clinical Trials

Changes in the Microenvironment of HPV-induced Head and Neck Cancers in West Indies and Metropolitan Population

MituHPV
Start date: December 7, 2017
Phase:
Study type: Observational

Retrospective observational comparative and multicentric study of the microenvironment of HPV-induced head and neck cancers, with comparison between West Indies and Metropolitan populations, and therapeutic implications. This assessment is carried out by in situ multiparametric study with multiple immunofluorescence staining for cluster of differentiation 3, cluster of differentiation 4, cluster of differentiation 8, PROGRAMMED DEATH-1, PROGRAMMED DEATH-L1, PROGRAMMED DEATH-L2, cytokeratin and cluster of differentiation 68 and automated reading. HPV genotypes will be characterized. Learning these techniques will allow me to promote them in West Indies on my way back, and they may be applicable to other HPV-induced cancers.

NCT ID: NCT03564743 Recruiting - Spondyloarthritis Clinical Trials

Description of Spondylarthritis and Validation of ASAS Criteria in West Indian Patients Seen in Consultation of Rheumatology.

SPACA
Start date: September 2015
Phase:
Study type: Observational

In 2004 an ASAS for the Assessment of SpondyloArthritis International Society decided to work to improve the criteria for classification of spondyloarthropathies to allow for early diagnosis, Nuclear magnetic resonance imaging (MRI). This approach led to the publication in 2009 of the classification criteria for spondylarthritis, in particular axial spondyloarthritis, as well as a proposal to modify the classification of criteria defined by Mr. Amor (AMOR) and European Spondylarthropathy Study Group (ESSG) criteria, taking into account the potential abnormalities visible in Magnetic Resonance Imaging Nuclear (MRI). The performance (specificity, sensitivity, positive and negative predictive values) of the ASAS criteria was then prospectively tested on a sample of the Metropolitan Caucasian population and this systematic study allowed to estimate the performance of the ASAS criteria in the usual framework Of the French Liberal Rheumatology Consultation. Note that this approach is exposed to a criticism of "circular" approach, indeed the expert who is the gold standard for the diagnosis, uses more or less consciously "criteria" based on the presence of such and such sign, then checks in this selected population the diagnostic validity of these signs. However, no data on the performance of ASAS criteria are available in populations of African descent.

NCT ID: NCT03429283 Completed - Clinical trials for Nosocomial Infection

Achromobacter Xylosoxidans (ACHX) Infections

ACHX
Start date: October 2016
Phase: N/A
Study type: Observational

Data extraction from bacteriological laboratory of Martinique University hospital to determine the frequency and the distribution of nosocomial infections due to Achromobacter xylosoxidans (ACHX), an emerging multi-resistant environmental bacteria. The specific tropical environment and climatic conditions in Martinique may favor ACHX development and the investigators suppose that this new opportunistic pathogen can represent a danger for hospitalized patients. The aim of our study is to describe the most affected population and try to identify the main environmental sources of contamination.

NCT ID: NCT03368300 Recruiting - Clinical trials for Atypical Parkinsonism

Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

CAP
Start date: August 3, 2012
Phase: N/A
Study type: Interventional

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.

NCT ID: NCT03368261 Completed - Sickle Cell Disease Clinical Trials

Epidemiology and Pathophysiological Mechanisms of HTAP in SS and SC Children in Martinique and Guadeloupe.

SAPOTILLE
Start date: January 11, 2010
Phase: N/A
Study type: Interventional

pulmonary arterial hypertension (PAH) has been reported with a prevalence of approximately 30% in adult sickle cell disease (SCD) patients, with an increased mortality in SCD patients with PAH, compared with those without PAH. The identification of several hemolysis biomarkers such as lactate dehydrogenase, bilirubin, reticulocytes or hemoglobin level, has clearly documented a link between hemolysis and PAH. However, other physiopathological mechanisms may be involved to explain PAH in these patients, such as pulmonary thromboembolism, pulmonary fibrosis or left heart diastolic and / or systolic dysfunction. The investigators suggest studying HTAP in patient's presenting the most frequent both drepanocytic syndromes, SS and SC and homogeneous in their medical coverage and the association between HTAP risk and specific SCD complications.

NCT ID: NCT03367650 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies

SLA-DOM
Start date: May 13, 2014
Phase: N/A
Study type: Interventional

The diagnosis and the follow-up of the patients reached of SLA is centralized, since a few years, at the the Caribbean Reference center of the rare neurological diseases (CERCA labélisé in 2006) in Martinique and at the Unity of coverage of the neuromuscular Diseases, SLA and the rare neurological diseases (create in 2010) in Guadeloupe. Several phenotypic characteristics seemed to us to take out again data collected during the follow-up of the patients (26 in Guadeloupe, since the creation of the unity) in particular patients' high proportion of exceptionally long evolution (more than 10 years). Besides, we diagnosed several cases (10 cases in Guadeloupe since 2000) of association SLA- Parkinsonien Syndrome. This association, considered as exceptional could establish a particular phenotypic entity which we would like to describe. We are interested also originally geographical of the patients, with the hypothesis that he could exist in the Antilles one or several geographical isolates of the disease allowing to lead a étiologique investigation in search of a possible genetic or environmental cause.

NCT ID: NCT03328338 Not yet recruiting - Cardiac Amyloidosis Clinical Trials

Mitochondrial Function in Transthyretin Amyloidosis

MIT-Amylose
Start date: January 2018
Phase: N/A
Study type: Observational

Hereditary (familial) amyloidosis arising from the misfolding of a mutated or variant transthyretin, is the most frequent form of amyloid cardiomyopathy in the Caribbean basin. Affected organs invariably harbor extracellular amyloid deposits in the myocardium. Circulating or pre-fibrillar amyloidogenic proteins are implicated in the disruption of cell function. Our aim is to demonstrate that transthyretin mediated amyloid disease alter the mitochondrial function of cardiac cells.