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NCT ID: NCT03316482 Recruiting - Clinical trials for Central Precocious Puberty

Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty

Start date: June 11, 2015
Phase: Phase 4
Study type: Interventional

A multicenter, open-label, prospective study to evaluate the safety and efficacy of leuprorelin acetate DPS (Leuplin DPS) treatment quarterly in patients with central precocious puberty

NCT ID: NCT03316352 Not yet recruiting - Ultrasonography Clinical Trials

Ultrasound-assisted Versus Conventional Landmark-guided Paramedian Spinal Anesthesia in Elderly Patients

Start date: October 20, 2017
Phase: N/A
Study type: Interventional

Multiple passes and attempts during spinal anesthesia might be associated with a greater incidence of paraesthesia, postdural puncture headache, and spinal hematoma. We hypothesized that the use of a preprocedural ultrasound-assisted paramedian technique for spinal anesthesia in patients with old age would reduce the number of passes required to entry into the subarachnoid space when compared with the landmark-guided paramedian approach. The study participants will be randomized into group L (landmark-guided) and group U (ultrasound-assisted). In group L, spinal anesthesia will be performed via paramedian approach using conventional landmark palpation technique. In group U, a preprocedural ultrasound scan will be used to mark the needle insertion site, and spinal anesthetic will be done via the paramedian approach.

NCT ID: NCT03315949 Enrolling by invitation - Clinical trials for Bowel Cleansing Efficacy

Comparison of Bowel Cleansing Efficacy Between Same-day Dose Versus Split Dose

Start date: May 1, 2017
Phase: Phase 3
Study type: Interventional

Split dose bowel cleansing is recommended method for colonoscopy. For afternoon colonoscopy, same-day dose of bowel cleansing is alternative option. Recently, same-day bowel cleansing for morning colonoscopy was validated. To date, there was no study which compared the bowel cleansing efficacy between same-day dose and split dose regardless of colonoscopy time. The aim of current study is to compare the bowel cleansing efficacy, adverse events, and patient's tolerability between the two group. Subjects who underwent colonoscopy for various reasons were included. After agreeing to participate in the study, study participants were randomly assigned to split dose or same day dose group. Bowel cleansing is done using polyethylene glycol (PEG). All colonoscopy was done between 10 AM to 6 PM. Study participants were instructed to ingest 500ml PEG every 15 minutes. Subjects who were assigned to split dose group ingested 2L PEG from 9PM 1 day before colonoscopy. Remaining 2L PEG was ingested 3-5 hours before colonoscopy. In the same-day dose group, bowel cleansing was started from 5AM for subjects who were scheduled to receive colonoscopy in the morning. Afternoon colonoscopy group in the same-day dose group ingested 2L PEG from 5AM. Remaining 2L PEG was finished 3-5 hours before colonoscopy. Bowel cleansing efficacy was assessed using Boston bowel preparation scale. Vital signs and laboratory tests were checked before colonoscopy. Study participants completed questionnaire which contained patient's satisfaction, tolerability, and adverse event during bowel cleansing. Bowel cleansing efficacy, patient's tolerability, and safety profile were compared between the two groups. Successful bowel cleansing was estimated 85% for split dose group. We set 10% for inferior margin. Considering 10% drop out, a total of 352 subjects will be recruited.

NCT ID: NCT03315598 Recruiting - Neuralgia Clinical Trials

Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

The investigators will evaluate the effectiveness and safety of acupuncture treatment in refractory neuropathic pain patients.

NCT ID: NCT03315364 Not yet recruiting - Clinical trials for Recurrent or Metastatic Breast Cancer

Oral Paclitaxel Trial In Recurrent and Metastatic Breast Cancer As 1st Line Therapy

OPTIMAL
Start date: November 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

To compare and evaluate the efficacy and safety of Liporaxel® solution (oral paclitaxel) and Taxol® (IV paclitaxel) on recurrent or metastatic breast cancer.

NCT ID: NCT03313453 Not yet recruiting - Allergic Rhinitis Clinical Trials

Effect of Air Cleaner on the Indoor Allergen Sensitized Allergic Rhinitis Patients

Start date: October 2017
Phase: N/A
Study type: Interventional

This study aimed to assess the impact of air cleanser on allergic rhinitis patients and indoor air quality. Air cleaners will be installed in the bedrooms and living rooms of the mite allergic rhinitis patients who aged 18-60 years. Main parameters: - Symptom medication score of allergic rhinitis Supportive parameters: - Visual analog scale of allergic rhinitis - Quality of life score of allergic rhinitis - Indoor air quality measurement - Indoor allergen level measurement

NCT ID: NCT03312647 Recruiting - Clinical trials for Latent Tuberculosis Infection

Adverse Drug Reactions to Anti-TB Drugs in the Treatment of Latent Tuberculosis Infection

Start date: June 19, 2017
Phase: N/A
Study type: Observational

The investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-related toxicity in LTBI in Korean health care workers(HCWs).

NCT ID: NCT03310385 Not yet recruiting - Acute Bronchitis Clinical Trials

Efficacy and Safety of GHX02 in the Treatment of Acute Bronchitis

Start date: January 2018
Phase: Phase 2
Study type: Interventional

This study is a phase 2, multicentre, dose-finding, double-blind, randomized placebo-controlled trial to evaluate the efficacy and safety of two different doses of GHX02, compared with placebo, for acute bronchitis. One-hundred and fifty patients will be included in this trial and randomly assigned to either a high-dose GHX02 group(1920mg/day), standard-dose GHX02 group(960mg/day), or control group(placebo) in a 1:1:1 allocation ratio. Patients will take one of the medications three times a day for 7 days, with 3 visiting days(screening, day0, day7). On the screening day, the Korean Standard Tool of Pattern Identification of Cough and Sputum, a diagnostic system that determines therapy in Traditional Korean Medicine, will be used to allocate patients into three groups of wind-heat, wind-cold or others.

NCT ID: NCT03309800 Completed - Acute Bronchitis Clinical Trials

A Clinical Trial to Evaluate the Efficacy and Safety of HL301 Versus Placebo in Acute Bronchitis Patients

Start date: March 29, 2017
Phase: Phase 2
Study type: Interventional

A Multicenter, Randomized, Double-blinded, Placebo-controlled, Parallel, Phase II Clinical Trial to Evaluate the Efficacy and Safety of HL301 versus Placebo in acute bronchitis patients. Endpoint: BSS, The improvement and improvement rate of the tester for the treatment response, The satisfaction of the subject, Total usage of Acetaminophen

NCT ID: NCT03308136 Recruiting - Clinical trials for Lumbar Radiculopathy Due to Spinal Nerve Compression

The Effect of Local Anesthetic Injection Depth on Procedural Pain and Discomfort During Fluoroscopically Guided Lumbar Transforaminal Epidural Injections

Start date: October 16, 2017
Phase: N/A
Study type: Interventional

Lumbar Transforaminal Epidural Injection is helpful for the treatment of lumbosacral radicular pain. But needle handling during the procedure may cause pain and discomfort to the patient. At the local skin anesthesia step, local anesthetics injection to the muscle layer along the needle pathway as well as the subcutaneous layer may reduce the procedural pain. In addition, it can reduce the injection site pain that may occur after the procedure.