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NCT ID: NCT03390387 Recruiting - Clinical trials for Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

ALL-MB 2015
Start date: November 2015
Phase: N/A
Study type: Interventional

QUESTIONS AND OBJECTIVES OF ALL-MB 2015 STUDY 1. Will the new risk group stratification (especially of T-ALL) to improve overall and event-free survival? 2. Will the new protocol is effective and feasible in patients older than 15 years, and especially in young adults? 3. Whether the intermittent dexamethasone administration in induction will result in a decrease in toxicity and mortality without loss of efficacy? 4. Whether the methylprednisolone administration as basic glucocorticoids during induction, consolidation and maintenance therapy will lead to decrease of severe infections and early mortality rate, improve survival and therapy compliance in adolescents and young adults with B-precursor ALL? 5. Whether the administration of Bortezomib in patients with B-precursor ALL with initial WBC≥100,000/µl will improve treatment outcome? 6. Whether the administration of Idarubicin instead Daunorubicin in low-risk T-ALL patients and two-phase induction in intermediate-risk T-ALL patients will reduce relapse rate and improve survival?

NCT ID: NCT03259269 Recruiting - Clinical trials for Tuberculosis, Multidrug-Resistant

Expand New Drugs for TB [endTB]

Start date: February 9, 2016
Phase: N/A
Study type: Observational

This observational study will examine the safety and efficacy of bedaquiline and delamanid used (individually, not together) in routine, multidrug regimens for treatment of MDR-TB. The information gathered in this study will inform doctors how best to use these TB drugs in the future.

NCT ID: NCT03225586 Recruiting - Cancer Clinical Trials

Prospective Urban Rural Epidemiology Study

PURE
Start date: January 1, 2002
Phase: N/A
Study type: Observational

To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g. death, non-communicable disease development) across a range of socioeconomic and health resource settings. Additional components of this study will examine genetic factors for non-communicable diseases. This will be examined both through a cross sectional component, and prospectively (cohort component).

NCT ID: NCT03177850 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on sleep related breathing disturbances at altitude in patients with COPD.

NCT ID: NCT03177837 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on exercise performance at altitude in patients with COPD.

NCT ID: NCT03177811 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on postural control at acute altitude exposure in patients with COPD.

NCT ID: NCT03173508 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on right ventricular function at acute altitude exposure in patients with COPD.

NCT ID: NCT03172429 Recruiting - Clinical trials for High Altitude Pulmonary Hypertension

Cerebral Tissue Oxygenation in Highlanders/Lowlanders

Start date: May 24, 2017
Phase: N/A
Study type: Observational [Patient Registry]

The purpose of the current study is to evaluate the cerebral tissue oxygenation of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participated in the study in 2012 to undergo follow-up examinations in 2017, in order to allow comparisons of current results with baseline data from 2012.

NCT ID: NCT03167034 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on right ventricular function during exercise at acute altitude exposure in patients with COPD.

NCT ID: NCT03165890 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease (COPD)

Effect of Acetazolamide on Cognition in Patients With Respiratory Disease at Altitude

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

Randomized, placebo controlled trial evaluating the effect of acetazolamide on cognition in lowlanders with chronic obstructive pulmonary disease travelling from 760 m to 3200 m.