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NCT ID: NCT03369327 Recruiting - Clinical trials for Human Immunodeficiency Virus

Sofosbuvir and Daclatasvir for Treating Hepatitis C in 200 Patients Co-infected With Human Immunodeficiency Virus

HIV200
Start date: January 1, 2017
Phase: Phase 3
Study type: Interventional

In a multi-center study 200 patients co-infected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) will be treated with a fixed-dose combination pill combined of 400 mg sofosbuvir and 30, 60, or 90 mg of daclatasvir - depending on the particular antiretroviral treatment (ART) being used by the patient. The treatment duration will be 12 weeks for subjects without cirrhosis and 24 weeks for those with cirrhosis.

NCT ID: NCT03366389 Completed - Clinical trials for Irritable Bowel Syndrome

Serum Levels of Apelin, Chemerin and Adiponectin Adipokines in Irritable Bowel Syndrome and Healthy Subjects

Start date: June 7, 2017
Phase: N/A
Study type: Observational

In this observational case-control study investigators aimed to assess the serum levels of adipokines such as Apelin, Chemerin and adiponectin in patients with irritable bowel syndrome (IBS), and compare it with healthy controls. Furthermore, investigators evaluated the possible correlation of these adipokines with IBS-QoL, IBSSS, GI symptoms and other clinical and psychological disorders.

NCT ID: NCT03353324 Recruiting - Clinical trials for Retinal Vein Occlusion With Macular Edema

Comparison of Therapeutic Effects Between Intravitreal Injection of Bevacizumab With Intravitreal Injection of Bevacizumab and Targeted Laser Photocoagulation of Non Perfused Areas of Retina in Patients With Acute Retinal Vein Occlusion

bevacizumab
Start date: November 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Patients with new onset retinal vein occlusion in less than 3 month whom has visual acuity less than 20/40 and central macular thickness more than 250micrometer and non perfused areas of retina more than 10 DD are included in over study and devided into 2 groups randomizely, Group A under gone 3 intravitreal injection of bevacizumab monthly and examine monthly for Visual acuity and central macular thickness, if in month four or more the CMT is more than 250 micrometer and the visual acuity is less than 8/10 the injection is repeated and follow up in this manner is continued until 9 months. Group B is as the same of group A but patients in this group undergone laser photocoagulation of retinal non perfused areas based on FAG wide field imaging . After 9 month follow up the outcomes such as Vusal acuity, Central macular thickness, intraocular pressure, neovascular formation are compared,

NCT ID: NCT03349216 Active, not recruiting - Clinical trials for Distal Radius Fracture

Bier's Block Versus Systemic Analgesia

Start date: October 20, 2017
Phase: Phase 2
Study type: Interventional

Background: There are three methods for procedural sedation in upper extremity traumas; systemic, regional and local anesthesia. There is controversy in the literature regarding the method of choice for this purpose. Objectives: The aim of this study was to compare conscious sedation and Bier's block methods for pain reduction in upper extremity trauma patients. Patients and Methods: This was a randomized clinical trial. Patients were randomly allocated to either the Bier's block or the conscious sedation group. Pain reduction was assessed by a numerical rating scale; patients, surgeons and physicians responsible for analgesia satisfaction were assessed using a five-point Likert scale. In this study, we aimed to compare the effectiveness, complications, duration, hemodynamic stability and patient and physician satisfaction between systemic analgesia and Bier's block method performed at the emergency department.

NCT ID: NCT03343548 Recruiting - Pain Clinical Trials

Epidural Magnesium Sulfate for Post-thoracotomy Pain Control

Start date: December 2016
Phase: N/A
Study type: Interventional

Pain after thoracotomy is very severe and may cause pulmonary complications. Thoracic epidural analgesia has greatly decreased the pain experience and its consequences. However, new ways of decreasing post-operative opioid drugs consumption is an important issue of research. We aim to evaluate the effect of adding epidural magnesium sulfate to bupivacaine and morphine on pain control and the amount of opioid consumption after thoracotomy. Eighty patients undergoing thoracotomy at a tertiary cardiothoracic referral center will be enrolled in a randomized double blind trial. Patients randomly will be allocated in two groups. Bupivacaine (12.5 mg) plus morphine (2 mg) will be administered epidurally for all patients at the end of operation. Patients in group I will be received epidural magnesium sulfate (50 mg) and patients in Group II will be received normal saline as an adjuvant. Visual analog scale (VAS) score and the amount of morphine consumption will be measured during 24 hours post-operation.

NCT ID: NCT03338153 Completed - Clinical trials for Coronary Artery Disease

Evaluation of Long-term Coronary Stenting Outcomes in Diabetic Patients With or Without Optimal Glycemic Control

Start date: October 2007
Phase: N/A
Study type: Observational

the purpose of this study is to determine whether appropriate control of diabetes around the PCI time is related with MACE and outcome of diabetic patients.

NCT ID: NCT03329664 Not yet recruiting - Clinical trials for Colon Cancer Stage II/III

Autologous Killer Cell Therapy in Colon Cancer Patients

Start date: January 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to evaluate the safety and efficacy of activated and expanded autologous cytokine-killer cells in controlling disease recurrence in patients with colon cancer. 20 patients with confirmed colon carcinoma who have had complete resection of primary lesions will be randomly assigned into two groups. Patients in both groups will receive the same therapeutic regimen as usual. Patients in one group additionally will be treated with several infusions of autologous killer cells that had been previously prepared from peripheral blood.

NCT ID: NCT03325686 Completed - Healthy Clinical Trials

Vitamin D Supplementation in Physical Performance

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

This study was performed to evaluate the efficacy of weekly vitamin D supplementation on athletic performance in Iranian athletes

NCT ID: NCT03315923 Not yet recruiting - Clinical trials for Progressive Multiple Sclerosis

Comparison of Clinical Effects of Rituximab and Glatiramer Acetate in Active Progressive Multiple Sclerosis Patients

Start date: December 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to compare annualized relapse rate, expanded disability status scale, Gad-enhanced brain lesions, and side effects after administration of rituximab and glatiramer acetate among patients with active progressive multiple sclerosis during a one year follow up through a randomized clinical trial.

NCT ID: NCT03308487 Recruiting - Clinical trials for Maternal Vitamin D Status

Vitamin D Supplementation and Pregnancy Outcomes

Start date: January 2017
Phase: N/A
Study type: Interventional

Groups (group 1 receives 1000 IU vitamin D and group 2 receives 2000 IU vitamin D) through a random allocation. It is necessary to mention that all cases in each group could be able to receive the current supplementation during pregnancy (Folic acid, iron and multivitamin and calcium). This study aimed to evaluate the efficacy of two doses of vitamin D supplementation (1000 and 2000 IU/d) during pregnancy on maternal and newborn vitamin D status and metabolic profile including lipid profile (serum concentration of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride(TG)), glucose homeostasis (fasting glucose, insulin, insulin resistance (HOMA-IR)) and inflammatory and oxidative stress (OS) markers and pregnancy outcomes including gestational diabetes, preeclampsia, preterm delivery, abortion, cesarian section, and also anthropometric data and apgar score of infants compared with placebo.