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NCT ID: NCT03531970 Completed - Local Anesthesia Clinical Trials

Effect of Lidocaine/Dexamethasone on the Success of IANB

Start date: August 1, 2016
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this prospective, randomized, double-blind study was to compare the success rate of IAN block injection carried out with two cartridges of 2% lidocaine with 1:80000 epinephrine each combined with 0.2 ml dexamethasone versus two cartridges of 2% lidocaine with 1:80000 epinephrine each combined with 0.2 ml sterile distilled water for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

NCT ID: NCT03514667 Recruiting - Metabolic Syndrome Clinical Trials

The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB)

Start date: May 30, 2018
Phase: N/A
Study type: Interventional

Metabolic syndrome is a public health challenge that includes a range of conditions including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. The syndrome is associated with an increase in the risk of Cardiovascular disease and death. Curcumin is a very active compound obtained from turmeric root. Curcumin has antioxidant and anti-inflammatory effects, and is also involved in the regulation of several signaling pathways. Since curcumin powder has low bioavailability, fast metabolism and low absorption, nanomicielle curcumin will be used in this study. Therefore, this study is planned to determine the effects of supplementation of nanomicielle curcumin on oxidative stress, systemic inflammation, adiponectin in serum and NF-kB in peripheral blood mononuclear cells in patients with metabolic syndrome.

NCT ID: NCT03499886 Recruiting - Procedural Sedation Clinical Trials

Low-Dose Intravenous Ketamine Bolus Versus Conventional Technique

Start date: January 17, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Abstract Background: Ketamine has been introduced as one of the most common drugs, administered to sedate children for different painful procedures in the emergency department (ED) but administration in higher dosage causes some severe complications. Thus, the aim of this study was to evaluate the effect of low-dose intravenous ketamine bolus versus conventional injection for reduction of upper and lower extremity fractures in children. Materials and Methods: In this randomized clinical trial, 198 participants with upper and lower extremity fractures were enrolled. The participants were divided randomly into two groups. In the intervention group, ketamine 1% was administered rapidly at a dose of 0.5 mg / kg (within 5 seconds), and in the control group, ketamine 1.5 mg / kg was slowly injected for 30 to 60 seconds. Then outcomes such as sedation depth and complications were measured for every two minutes and satisfaction of participants and physicians were recorded. Results: Results showed that the successful sedation rate in the low dose ketamine group was significantly lower, as compared to the control group (7% vs 100%) (p<0.001). Moreover, In terms of duration of drug effect and of recovery, the low dose ketamine group were significantly lower compared with the group receiving higher dosage of ketamine (p<0.05). Furthermore, the sedation depth based on Wisconsin Sedation Scale was significantly higher, in the low dose ketamine group compared to the other group. By evaluating different complications, we found that the rate of neurological (20.4 % vs 5%) and physiological (10.2% vs 2%) complications in the control group was significantly higher compared to the group receiving low-dose ketamine (p<0.05).

NCT ID: NCT03488836 Recruiting - Clinical trials for Endodontically Treated Teeth

Evaluation the Post Operative Pain of Endodontic Treated Molar Tooth With Race and Reciprocal Systems Among Bandarabbas Patients in 2017

Start date: May 2, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

extrusion of infected dentin into the periapical tissue has been suggested as a major source of pain after endodontic treatment. Although debris extrusion is an inevitable finding even when instrumentation is limited to the confines of the canal, different armamentarium seem to be associated with different amounts of debris extrusion. Studies on the effect of various rotary files on post-endodontic pain are very few and have yielded conflicting results with some favoring full-sequence and others leaning towards reciprocal rotary systems. This study aims at assessing the intensity of post-endodontic pain following two different rotary systems, Reciproc and race. Methods: in this single-blind, parallel-grouped randomized clinical trial a total of 150 otherwise healthy patients aged between 20 to 50 years old with a pulpal status of irreversible pulpitis for one tooth in the upper or lower molar region were analyzed. A clinician performed the endodontic treatment in two groups, a group instrumented using race and a third group with instrumentation performed using Reciproc rotary systems.

NCT ID: NCT03468686 Completed - Clinical trials for Major Depressive Disorder

The Study of Effectiveness of rTMS on Anhedonia and Rumination in Patients With MDD

Start date: December 21, 2016
Phase: N/A
Study type: Interventional

This study aims to compare the effectiveness of rTMS on the reduction of anhedonia and rumination and their associated neural networks. In a randomized double-blind trial, 45 patients with major depressive disorder (MDD) in Atieh Clinical Neuroscience Center are assigned to two groups. The first group receives bilateral rTMS for 10 sessions on DLPFC; the second group receives sham rTMS for 10 sessions. In this group, the stimulation parameters are similar to that in the actual rTMS group, except that the coil angel is 90° and perpendicular to the head. Anhedonia symptoms will be measured by the Snaith-Hamilton Pleasure Scale (SHAPS), and rumination symptoms will be measured by the Ruminative Responses Scale (RRS) in the baseline and in the end of 10th session. In order to investigate neural networks associated with Anhedonia and rumination, EEG of patients will be recorded at the first session and at the end of the treatment.

NCT ID: NCT03466645 Not yet recruiting - Clinical trials for Elective Craniotomy-candidated Patients

The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy

Start date: April 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Surgical-site infection is the most commonly reported nosocomial infection in patients undergoing surgery and 3rd most nosocomial infection in hospitalized patients. The SSI is associated with increases of length of hospitalization for 6 days and increases the hospital's cost by $ 300. Because of these, prevention of SSI with appropriate antibiotic is essential.

NCT ID: NCT03459560 Active, not recruiting - Clinical trials for Cardiovascular Diseases

Prevention of Cardiovascular Disease With Polypill Among Pars Cohort Participants

Start date: December 20, 2014
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the effects of a fixed dose combination of enalapril, hydrochlorthiazide, atorvastatin and acetylsalicylic acid (PolyPill) on primary and secondary prevention of cardiovascular disease in participants of Pars Cohort of Iran.

NCT ID: NCT03431454 Recruiting - Clinical trials for Comparison of Three Vision Therapy Approaches for Convergence Insufficiency

Comparison of Three Vision Therapy Approaches for Convergence Insufficiency

Start date: February 2018
Phase: Phase 2
Study type: Interventional

We compared the effectiveness of three active vision therapy approaches for convergence insufficiency (CI). Patients with eligible criteria and symptomatic CI were included in a prospective study and randomly allocated into three groups. In the home-based vision orthoptic therapy (HBVOT) group, patients were trained to do the pencil push-ups procedure 15 minutes per day, five days a week. In the office-based vision orthoptic therapy (OBVOT) group, 60 minutes of orthoptic therapy using a major amblyoscope twice weekly with additional home orthoptic therapy was prescribed. For the augmented office-based vision orthoptic therapy (AOBVOT) group, orthoptic exercises using three diopter over-minus lenses and a base out prism, in addition to major amblyoscope and additional home reinforcement was prescribed in the same period of time.

NCT ID: NCT03427918 Recruiting - Epilepsy Clinical Trials

The Effectiveness of the Mindfulness-based Cognitive Therapy (MBCT) on Sexual Functioning in Epileptic Women

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

Female sexual dysfunction (FSD) includes impairments in sexual desire, arousal, orgasm, and genital pain resulting in significant subjective distress. This study is aimed to assess a mindfulness-based intervention for improving sexual functioning among women with epilepsy

NCT ID: NCT03425656 Recruiting - Clinical trials for Malignant Neoplasm of Breast

Comparing Efficacy and Safety of AryoGen Pharmed Biosimilar Trastuzumab (AryoTrust®) Versus Herceptin® in Breast Cancer

Start date: July 9, 2016
Phase: Phase 3
Study type: Interventional

This is A Phase III, randomized, two-armed, patient-outcome assessor-data analyzer blinded, parallel active controlled non-Inferiority clinical trial study to evaluate efficacy and safety of AryoTrust™ (Aryogen Trastuzumab in comparison to Herceptin® (Genentech/Roche) in patients with Human Epidermal Growth Factor Receptor 2-Positive breast cancer. The main objective is to verify the non-inferiority of AryoTrust™ (Aryogen trastuzumab) vs. Herceptin® (Genentech/Roche trastuzumab), both given concomitantly with docetaxel after doxorubicin plus cyclophosphamide in the neoadjuvant setting according to pathological complete response (pCR) as primary objective and objective response (cOR), clinical complete response (cCR), clinical partial response (cPR), clinically no change (cNC), clinical progressive disease (cPD), breast conservation rate as Secondary objectives of this study. Evaluating the safety and immunogenicity of AryoTrust™ vs. Herceptin®, are also the other secondary outcomes. This study has two arms and 108 subjects will participate with a 1:1 allocation and receive mentioned treatment randomly.