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NCT ID: NCT06270693 Active, not recruiting - Clinical trials for Coronary Artery Disease

hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary Artery Disease without chronic pulp exposure.

NCT ID: NCT06240182 Active, not recruiting - Periapical Lesion Clinical Trials

Effect of Piezoelectric Device on Intraoperative Hemorrhage Control and Quality of Life

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

Most osteotomies and apicoectomies in periapical surgeries are performed by surgical carbide or diamond burs. But greater pressure is applied during cutting which causes more thermal and mechanical damage to the bone. Also, when it comes in contact with soft tissues like nerves or vessels it results in profuse bleeding which affects vision in surgery and neurosensory disturbance at a later stage along with the deposition of metal shavings and bony particles resulting in impaired healing. The main advantages of piezoelectric surgery in various studies are highlighted as selective hard tissue cutting and sparing soft tissue, so even if it comes in contact with vessels, nerve or Schneiderian membrane it does not result in profuse bleeding, postoperative nerve damage or perforation.

NCT ID: NCT06240169 Active, not recruiting - Pulpitis Reversible Clinical Trials

Effect of Age on the Success of DPC Using Bio-ceramic Materials in Cariously Exposed Teeth With Reversible Pulpitis

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Study Title: - Effect of age on the success of direct pulp capping using bio-ceramic materials in cariously exposed teeth with reversible pulpitis: A Prospective clinical study. Rationale: - Preservation of pulp vitality is a critical factor in long-term tooth survival. In deep carious lesion with reversible pulpitis, vital pulp therapy procedures in the form of direct pulp capping(DPC)is more conservative treatment strategy, based on the premise that a biologically active material placed in direct contact with the pulp wound can determine the pulpal response and result in the development of a reparative hard tissue bridge to preserve pulp vitality. Patient's age may have a role in the survival rate after direct pulp capping and the role of the pulp capping material has been recognized as an important parameter for the success of treatment. Research Question : Does age has any influence on the success of DPC procedure and is there any difference between MTA and Biodentine as DPC material in cariously exposed permanent teeth with reversible pulpitis? Aim & Objectives- To evaluate the effect of age on success of Direct Pulp Capping, to evaluate the success of MTA and Biodentine as direct pulp capping agents.

NCT ID: NCT06240130 Active, not recruiting - Clinical trials for Irreversible Pulpitis

Outcome Following Use of NaOCl and Chlorhexidine as Wound Lavage Agents

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to to compare effect of wound lavage agents NaOCl and Chlorhexidine on the outcome of partial pulpotomy in mature permanent posterior teeth with signs and symptoms indicative of irreversible pulpitis in. The main question it aims to answer are: Does wound lavage using chlorhexidine have equal effect as NaOCl on the outcome of partial pulpotomy in mature permanent mandibular posterior teeth with clinical signs of irreversible pulpitis? Participants will of age group 18 to 45 years will be included and divided into two groups: Pulp wound lavage in partial pulpotomy using 3% NaOCl as control and using 2% Chlorhexidine as experiment

NCT ID: NCT06220890 Active, not recruiting - Clinical trials for Class IV Dental Caries

Clinical Performance of Two Different Bevel Preparations in Class IV Lesions Using Nanofilled Composite

Start date: June 22, 2022
Phase: N/A
Study type: Interventional

The purpose of the study is to compare and evaluate clinical performance between two different bevel preparations in Class IV lesions using nano-filled composite restorations.

NCT ID: NCT06192706 Active, not recruiting - Clinical trials for Aortic Valve Stenosis

Clinical Investigation for the Foldax Tria Aortic Heart Valve- India

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to conduct a clinical investigation of the Foldax Tria Aortic Valve to collect evidence on the device's safety and performance.

NCT ID: NCT06191718 Active, not recruiting - Clinical trials for Mitral Regurgitation

Clinical Investigation for the Foldax Tria Mitral Valve- India

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to conduct a clinical investigation of the Foldax Tria Mitral Valve to collect evidence on the device's safety and performance.

NCT ID: NCT06179433 Active, not recruiting - Clinical trials for Apical Periodontitis

Outcome of Regenerative Endodontic Procedure and Root Canal Treatment for the Management of Apical Periodontitis

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

Background Root canal therapy is the primary treatment of choice for necrotic mature teeth with periapical lesions (PRLs), which does not restore the tooth's vitality. Provided that injectable platelet-rich fibrin (i-PRF) has shown promising results in regenerative medicine as a novel platelet concentration, the purpose of this study is to ascertain whether i-PRF, as opposed to blood clot (BC), can serve as a biological scaffold, thereby expanding the indications for regenerative endodontic procedures (REPs) in mature teeth. Novelty There is no study available that has evaluated the outcome of REP in the necrotic mature mandibular molars with periapical lesions. Furthermore, the efficacy of novel i-PRF as a scaffold in REPs remains to be explored. Objectives To evaluate and compare the outcome of REPs in comparison to conventional RCT in necrotic mature molars with PRLs and to evaluate the efficacy of i-PRF and BC in REP as a scaffold. Secondary objective is to evaluate pain for first postoperative week and subjective responses to pulp sensibility tests at 12 months follow-up. Method 120 patients presenting with necrotic pulp and periapical lesions will be randomly allotted to one of the three groups - REP using i-PRF or BC or RCT group. Comparative evaluation of outcome of REP and RCT will be performed at 12-months follow-up.

NCT ID: NCT06168097 Active, not recruiting - Endometriosis Clinical Trials

The Use of MicroRNAs Dysregulation as Potential Biomarkers for Effective Diagnosis of Endometriosis

ENDMET
Start date: November 15, 2023
Phase: N/A
Study type: Interventional

OBJECTIVES : 1. To investigate the expression pattern of miRNAs operational in inflammation, angiogenesis, hypoxia, apoptosis and cell proliferation in eutopic and ectopic endometrium of patients with endometriosis and normal endometrium of healthy controls. 2. To understand the function of candidate predictive miRNAs for endometriosis by investigating their downstream targets and associated biological pathways. 3. Evaluation of significant outcome of objective 1 in serum samples to establish them as biomarkers. Study Design: Case control study. sample size: 200

NCT ID: NCT06036394 Active, not recruiting - CNS Tumor Clinical Trials

Artificial Intelligence in CNS Radiation Oncology

AI-RAD
Start date: September 13, 2023
Phase:
Study type: Observational

Radiotherapy involves the use of high-energy X-rays, which can be used to stop the growth of tumor cells. Radiotherapy constitutes an essential avenue in the treatment of brain tumors. The modern techniques of radiotherapy involve radiation planning techniques guided by computer algorithms aimed to deliver high doses of radiation to the areas of brain with tumors and limit the doses to surrounding normal structures. Artificial intelligence uses advanced analytical processes aided by computational analysis, which can be undertaken on the medical images, and radiation planning process. We plan to use artificial intelligence techniques to automatically delineate areas of the brain with tumor and other normal structures as identified from images. Also, we will use artificial intelligence on the radiation dose images and other images done for radiation treatment to classify tumors with good or bad prognoses, identify patients developing radiation complications, and detect responses after treatment.