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NCT ID: NCT03297177 Not yet recruiting - Dementia Clinical Trials

Autologous Stem/Stromal Cells in Neurological Disorders and Disease

NDD
Start date: October 15, 2017
Phase: N/A
Study type: Interventional

The study deals with evaluation of safety and efficacy of use of stem/stromal cell isolates from autologous microvasculature in neurological, non-neoplastic disease. Autologous cells are acquired via microcannula aspiration of subdermal fat deposits, isolated through a digestive process, and concentrated via standard centrifugation. The cellular stromal vascular fraction (cSVF) created is neutralized and rinsed to eliminate residual enzymatic molecules. These cells are suspending in sterile Normal Saline Solution (500cc) and re-administered via an intravenous parenteral route, passed through a standard sterile 150 u (micron) filter in line. Multiple tracking and questionnaire followup is intended over a 5 year period, with objective and subjective criteria being met. Compilation and analysis of data to be completed after that period.

NCT ID: NCT03208816 Recruiting - Depression Clinical Trials

Community-Led Action Research in Oncology: Improving Symptom Management

CLARO
Start date: July 24, 2017
Phase: N/A
Study type: Interventional

This study will be conducted at La Liga Contra el Cancer in San Pedro Sula, Honduras. The overall objective of this project is to improve symptom management for patients undergoing chemotherapy in Honduras. The first step in this line of research is a "proof of concept" feasibility study in which the investigators will demonstrate their ability to train nurses to administer a non-pharmacological, telephone-delivered, symptom management program for chemotherapy patients.

NCT ID: NCT03158233 Recruiting - Zika Virus Disease Clinical Trials

Zika Case Definition and Surveillance Study

Start date: April 29, 2017
Phase: N/A
Study type: Observational

This prospective, surveillance study will assess the operational Zika virus definition for use in future Zika purified inactivated virus (ZIKV) vaccine efficacy trials in order to identify Zika virus disease (ZVD) cases among the study cohort.

NCT ID: NCT03107611 Completed - Atopic Dermatitis Clinical Trials

Bioequivalence Study of Pimecrolimus Cream, 1% and Elidel® Cream, 1% in Mild to Moderate Atopic Dermatitis

Start date: February 29, 2016
Phase: Phase 3
Study type: Interventional

To establish the bioequivalence between test drug, Pimecrolimus Cream, 1% with that of reference listed drug, Elidel® (pimecrolimus) Cream 1%, in the treatment of mild to moderate Atopic Dermatitis. To establish superiority of each active treatment over the placebo.

NCT ID: NCT02987855 Recruiting - Fibromyalgia Clinical Trials

Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia

ADcSVF-CRPS
Start date: December 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), Causalgia, and Fibromyalgia represent progressive systemic pain conditions which often worsen over time. They appear to be dysregulation of the central nervous system (CNS) and the autonomic system (sympathetic/parasympathetic) which cause extensive functional losses, impairment, and disabilities. They are often associated with injury sites (including surgical) which produce constant, often disabling pain and motor-sensory losses. Treatments are often ineffective and include medications (often high dose opiates), Physical Therapy (PT), and surgical interventions (sympathectomy, ablation) or insertion stimulators of the CNS. Study is an interventional study to document the safety and efficacy of use of adipose-derived cellular stromal vascular fraction (AD-cSVF) in chronic pain and dysfunction disease groups.

NCT ID: NCT02946658 Recruiting - Lung Disease Clinical Trials

Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells In Chronic Lung Disorders

ADcSVF-COPD
Start date: October 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Chronic Obstructive Pulmonary Disease (COPD) is a lung-related disorder that is characterized by long-term, often progressive state of poor airflow. Primary symptoms include low oxygen tension, shortness of breath, productive cough, and broncho-pulmonary inflammation and interference with oxygen-carbon dioxide exchange. Air pollution and tobacco smoking are felt to be the most common cause of these issues. Diagnostic testing is based on poor airflow measured by lung function studies and whose symptoms do not improve much with antiasthma bronchodilators. Study is an interventional study to document the safety and efficacy of use of AD-cSVF in chronic broncho-pulmonary disease groups.

NCT ID: NCT02945657 Completed - Atopic Dermatitis Clinical Trials

Pharmacokinetics and Safety of MM36 Topical Ointment in Pediatric Subjects With Atopic Dermatitis

Start date: October 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the pharmacokinetic parameters and safety of topical MM36 (OPA-15406) ointment in pediatric subjects with atopic dermatitis under maximal use conditions.

NCT ID: NCT02939859 Recruiting - Multiple Sclerosis Clinical Trials

Use of Cellular Stromal Vascular Fraction in Multiple Sclerosis,Autoimmune, Inflammatory, Neurologic Conditions

cSVF
Start date: September 2016
Phase: N/A
Study type: Interventional

Purpose of study is to determine safety and efficacy of use of autologous Adipose-Derived cellular Stromal Vascular Fraction (AD-cSVF) suspended in Normal Saline and delivered via intravascular system of quality of life and alteration of documented Muscular Sclerosis (MS) and related neurodegenerative patients. It is believed that the heterogeneous cell population which includes multipotent stem/stromal cells are capable of immune modulation/inflammatory modulation properties. Exam of disease progression and quality of life changes will be evaluated.

NCT ID: NCT02796066 Withdrawn - Acne Vulgaris Clinical Trials

TSN2898-201 Safety and Efficacy of TSN2898 in the Treatment of Acne Vulgaris

Start date: June 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of TSN 2898 topical gel in the treatment of moderate to severe acne.

NCT ID: NCT02794428 Recruiting - Gastric Cancer Clinical Trials

Chemoprevention of Gastric Carcinogenesis

Start date: September 19, 2016
Phase: Phase 2
Study type: Interventional

A clinical study of the efficacy of oral alpha-difluoromethylornithine (eflornithine or DFMO) in male and female subjects ages 30-60 with gastric premalignant lesions in two high risk regions of Latin America.