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NCT ID: NCT03373396 Completed - Fibrosis, Liver Clinical Trials

Impact of Chlordecone on Active Chronic Hepatitis

Start date: November 8, 2011
Phase: N/A
Study type: Interventional

Chlordecone is known to induce liver damage in rat and mice but no data exists in human being. However chlordecone was used until 1993 in French West Indies for banana fields, it is important to test what damage can be induced now, for patients exposed. We should consider chlordecone as a potential cofactor of liver fibrosis. So we have chosen to compare two populations of chronic hepatitis B, C or alcoholic, with cirrhosis or without fibrosis due to active hepatitis, who had been exposed to chlordecone.

NCT ID: NCT03373357 Active, not recruiting - Clinical trials for Hypertension Arterial

Hypertension and Cardiovascular Risk Associated With Obstructive Sleep Apnea in Adult in Guadeloupe (French West Indies)

Start date: September 9, 2008
Phase: N/A
Study type: Interventional

The MAPA is the reference method to estimate the PA during the SAHOS. The MAPA can be recommended over 48 hours: indeed, the PA falls at the beginning of every apnea then increases gradually up to a pressif peak arising at the time of the ventilatoire resumption. These variations arise under the influence of 4 stimulus: the désaturation in O2, the rise of the PaCO2, the increase of the respiratory effort and the microawakening of the end of apnea who are at the origin of a sympathetic stimulation. Consequently a better diagnostic approach of the HTA (confirmation of a resistant HTA, an identification of the masked HTA and the patients " not dipper " by the MAPA), the identification of the SAHOS, and a better coverage) of the associated cardiovascular risk factors are essential and establish a stake in public health. To investigator's knowledge, no datum or study on the association HTA-SAHOS and its consequences was until then realized in the French overseas departments.

NCT ID: NCT03368924 Completed - Sickle Cell Disease Clinical Trials

Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:

Start date: April 9, 2013
Phase: N/A
Study type: Interventional

Despite important advances in the current understanding of sickle cell vaso-occlusion, the basis of its control and prevention remain partially unknown. The primary purpose is to test the hypothesis of a control of the sickle cell vaso-cocclusive (VOC) process by the anti band 3 antibodies by assessing the level of these antibodies in the steady state and during the crises in SCA patients. To assess the relationship between the level of band 3 antibodies, the oxidation status, the expression of microparticles and the hemorheological alterations of the sickle red cells (SS RBs), the severity of VOC.

NCT ID: NCT03367650 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies

Start date: May 13, 2014
Phase: N/A
Study type: Interventional

The diagnosis and the follow-up of the patients reached of SLA is centralized, since a few years, at the the Caribbean Reference center of the rare neurological diseases (CERCA labélisé in 2006) in Martinique and at the Unity of coverage of the neuromuscular Diseases, SLA and the rare neurological diseases (create in 2010) in Guadeloupe. Several phenotypic characteristics seemed to us to take out again data collected during the follow-up of the patients (26 in Guadeloupe, since the creation of the unity) in particular patients' high proportion of exceptionally long evolution (more than 10 years). Besides, we diagnosed several cases (10 cases in Guadeloupe since 2000) of association SLA- Parkinsonien Syndrome. This association, considered as exceptional could establish a particular phenotypic entity which we would like to describe. We are interested also originally geographical of the patients, with the hypothesis that he could exist in the Antilles one or several geographical isolates of the disease allowing to lead a étiologique investigation in search of a possible genetic or environmental cause.

NCT ID: NCT03362762 Completed - Clinical trials for Type 2 Diabetes Treated With Insulin

Characteristics of Type 2 Diabetes Patients, Treated With Insulin and Their Follow up Care in Guadeloupe

Start date: December 16, 2013
Phase: N/A
Study type: Observational

Type 2 diabetes is a major problem of public health in the French West Indies, with an estimated prevalence of 8%, twice more than in France. In Guadeloupe, according to the statistical data of hospital morbidity in 2004, 2643 hospital stays were diagnosed with diabetes. These cases mainly concerned woman (62%) and the elderly, from 45 to 74 years old (67%). The main objective of this research is to describe the insulin protocol used in Guadeloupe for treated type 2 diabetes patients and their characteristics: - The duration of the type 2 diabetes - Time elapsing between the diagnosis and the treatment by insulin - Where the follow up care took place - Existence of complications Secondary objectives were to describe the link between the HbA1c rate and the insulin therapy protocol. And also to present the main inconveniences expressed by patients and their degree of autonomy.

NCT ID: NCT03322319 Completed - Clinical trials for Left Ventricular Hypertrophy

Frequency of Cardiac Amyloidosis in the Caribbean's. (TEAM Amylose)

Start date: September 23, 2013
Phase: N/A
Study type: Interventional

The frequency of cardiac amyloidosis among patients presenting with a so-called left ventricular hypertrophy remains unknown. This problem is especially relevant in the Caribbean's, where an amyloidosis-prone mutation of transthyretin gene might be frequent.

NCT ID: NCT03306251 Recruiting - Clinical trials for Mother to Child Transmission of HIV

National Cohort of Children Born to HIV-positive Mothers

Start date: June 2005
Phase: N/A
Study type: Observational

The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.

NCT ID: NCT03188731 Recruiting - Pregnancy Related Clinical Trials

ZIKAlliance Pregnant Women Cohort

Start date: May 24, 2017
Phase: N/A
Study type: Observational

The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations. We will estimate the absolute and relative risks of congenital malformations and other adverse outcomes of pregnancy among women who become infected with ZIKV during pregnancy compared to uninfected pregnant women, also leading to further validation of the Congenital Zika Syndrome.

NCT ID: NCT03161444 Recruiting - HIV Infections Clinical Trials

Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection.

Start date: March 21, 2017
Phase: N/A
Study type: Interventional

This study will estimate the cumulative incidence of Zika infection at the end of the first epidemic in the French West Indies in a sample of patients followed for HIV infection.

NCT ID: NCT02874456 Active, not recruiting - Viruses Clinical Trials

Pilot Study to Detect Zika Virus in Sperm

Start date: May 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to seek the presence of ZIKV in semen, to determine its localization and to assess the efficiency of spermatozoa processing methods to obtain virus free spermatozoa.