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NCT ID: NCT03695770 Recruiting - Malaria Clinical Trials

Evaluation of a New Malaria Control Strategy Amongst Gold Miners Working Illegally in French Guiana (Malakit)

MALAKIT
Start date: April 16, 2018
Phase: N/A
Study type: Interventional

Illegal gold miners in French Guiana, a French overseas territory ('département') located in Amazonia, often carry malaria parasites (up to 46.8%). While the Guiana Shield Region aims at malaria elimination, the high prevalence of Plasmodiumin this hard-to-reach population in conjunction with frequent incorrect use of artemisinin-based anti-malarials could favor the emergence of resistant parasites. Due to geographical and regulatory issues in French Guiana, usual malaria control strategies cannot be implemented in this particular context.Therefore, new strategies targeting this specific population in the forest are required. Numerous discussions among health institutions and scientific partners from French Guiana, Brazil and Suriname have led to an innovative project based on the distribution of kits for self-diagnosis and self-treatment of Plasmodium infections. The kit-distribution will be implemented at "resting sites", which are areas across the border of French Guiana regularly frequented by gold miners. The main objective is to increase the appropriate use and complete malaria treatment after a positive malaria diagnosis with a rapid test, which will be evaluated with before-and-after cross-sectional studies. Monitoring indicators will be collected from health mediators at the time of kit distribution and during subsequent visits, and from illegal gold miners themselves, through a smartphone application. The project funding is multisource, including Ministries of Health of the three countries, WHO/PAHO, and the European Union.

NCT ID: NCT03427190 Recruiting - Suicide Attempt Clinical Trials

Suicide Prevention Algorithm in the French Overseas Territories

APSOM
Start date: October 9, 2017
Phase: N/A
Study type: Interventional

In France, suicide behaviours are a major public health concern that triggered the creation in 2013 of a National Observatory of Suicide. In continental France, the "Algos" protocol was found to be effective for the prevention of suicide attempts reiterations. This protocol is based on a procedure that keeps telephone and postal contacts with the suicide attempter and allows, via an algorithm, to assess the risk of suicide attempt recurrence, in order to intervene if necessary. Nevertheless, Algos does not involve primary care health practitioners, who could add a substantial additional efficacy, especially if they intervene downstream and in supplement to Algos. In addition, this kind of protocol has never been evaluated in the French overseas territories.

NCT ID: NCT03368300 Recruiting - Clinical trials for Atypical Parkinsonism

Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

CAP
Start date: August 3, 2012
Phase: N/A
Study type: Interventional

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.

NCT ID: NCT03306251 Recruiting - Clinical trials for Mother to Child Transmission of HIV

National Cohort of Children Born to HIV-positive Mothers

EPF
Start date: June 2005
Phase: N/A
Study type: Observational

The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.

NCT ID: NCT02516579 Active, not recruiting - Sickle Cell Disease Clinical Trials

European Sickle Cell Disease Cohort - Hydroxyurea

ESCORT-HU
Start date: January 2009
Phase:
Study type: Observational

In the context of the Risk Management Plan (RMP), as requested from Addmedica by the EMEA, to collect information about long-term safety of Siklos® (hydroxycarbamide) when used in patients with Sickle Cell Disease.