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NCT ID: NCT03873909 Completed - Clinical trials for Biological Availability

Bioavailability of Carotenoids Present in Mamey Sapote (Pouteria Sapota (Jacq.) H. E. Moore & Stearn) Fruit

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

The goal of the study is to determine if mamey sapote fruit, rich in rare potentially provitamin A keto-carotenoids, is a good source of vitamin A in humans. Furthermore, it will help to compare the absorption of carotenoids between the fruit versus a "matrix-free" formulation. The objective will be accomplished by quantitation of the immediate post-prandial plasma concentrations of parent carotenoids and vitamin A metabolites from participants consuming a meal consisting of a mamey sapote fruit smoothie or a shake containing mamey sapote encapsulated carotenoids.

NCT ID: NCT03852290 Recruiting - Colon Cancer Clinical Trials

C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine Effectiveness in Metastatic Colon Cancer

Start date: January 16, 2019
Study type: Observational

Fluoropyrimidines are the backbone of chemotherapy regimes used to treat metastatic colorectal cancer (CRC). These drugs act in different pathways of folate metabolism altering DNA synthesis mainly by inhibition of the tymidylate synthase. For this reaction the 5,10-methylenetetrahydrofolate acts as cofactor. It has been demonstrated that A1298C and C677T polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene result in reduced enzyme activity that leads to reduced availability of this important cofactor. Hence, we hypothesized that the presence of these polymorphisms are related to the efficacy and toxicity of fluoropyrimidines in patients with CRC.

NCT ID: NCT03728881 Recruiting - Cervical Cancer Clinical Trials

Immunogenicity From 1 Dose of Bivalent HPV Vaccine in Girls to 3 Doses of Quadrivalent Vaccine in Women: the PRIMAVERA-ESCUDDO Trial

Start date: May 22, 2019
Phase: Phase 3
Study type: Interventional

Background: Cervical cancer is a dangerous disease caused by a germ called human papillomavirus (HPV). There are 3 safe vaccines that protect women against HPV and cancer. Currently, girls receive 2 doses of HPV vaccine. Researchers want to test if only 1 dose is enough. This study in Costa Rica is one of several new 1-dose studies being done around the world. Objective: To find out if giving only 1 dose of the HPV vaccine Cervarix to young girls works the same as giving 3 doses of the HPV vaccine Gardasil to young women. Eligibility: Healthy girls ages 9-14 Healthy women ages 18-25 Design: Participants will be screened with blood and urine tests and questions about their health. Their parents may answer some of the questions. Participants will get the vaccine as an injection in the arm. They will be observed for 15 minutes each time they get the vaccine. Participants ages 9-14 will get the Cervarix vaccine 1 time. Six months later, participants (or their parents) will be asked about their health. This contact will be a phone call and will take about 5 minutes. Participants ages 18-25 will get the Gardasil vaccine 3 times over 6 months. All participants will have 1 half-hour visit every year for 3 years after getting the vaccine. This can be at the clinic or the participant s home. Participants and/or their parents will answer questions about the participant s health and any vaccines they received since the last contact. Participants will give a blood sample.

NCT ID: NCT03653364 Recruiting - Influenza Clinical Trials

Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants From Birth to < 1 Year With Influenza-Like Symptoms

Start date: January 23, 2019
Phase: Phase 3
Study type: Interventional

This study will evaluate the safety, pharmacokinetics and efficacy of baloxavir marboxil in healthy pediatric participants from birth to <1 year with influenza like symptoms

NCT ID: NCT03629184 Completed - Influenza Clinical Trials

Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms

Start date: November 20, 2018
Phase: Phase 3
Study type: Interventional

This study will evaluate the safety, pharmacokinetics, and efficacy of baloxavir marboxil compared with oseltamivir in a single influenza episode in otherwise healthy pediatric participants (i.e., 1 to <12 years of age) with influenza-like symptoms.

NCT ID: NCT03549754 Recruiting - Type 2 Diabetes Clinical Trials

DISCOVER Global Registry

Start date: February 17, 2018
Study type: Observational [Patient Registry]

To provide real world data on patient characteristics, disease management, healthcare utilization, and outcomes in patients with type 2 diabetes and established micro- and/or macrovascular disease

NCT ID: NCT03523858 Recruiting - Clinical trials for Progressive Multiple Sclerosis (PMS)

A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

Start date: May 28, 2018
Phase: Phase 3
Study type: Interventional

This study is a prospective, multicenter, open-label, single-arm effectiveness and safety study in participants with progressive multiple sclerosis (PMS).

NCT ID: NCT03492619 Completed - Obesity Clinical Trials

Intervention for Women in Costa Rica

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

The study develops, implements, and evaluates an intervention focused on alleviating discouragement, food insecurity, and excess weight in women,targeted at the individual, family, and community levels in the Canton Central of the province of Alajuela, Costa Rica.

NCT ID: NCT03477630 Recruiting - Osteoarthritis Clinical Trials

Treatment of Osteoarthrosis of the Knee With Platelet Rich Plasma, Comparative Study With Hyaluronic Acid

Start date: February 14, 2019
Phase: Phase 3
Study type: Interventional

This study is using Plasma Rich Platelets to improve the negative symptoms of adult patients with osteoarthrosis of the knee. Half of the patients receive Plasma Rich Platelets. The other half receives hyaluronic acid.

NCT ID: NCT03470103 Recruiting - Clinical trials for Macular Degeneration

A Study in Patients With Wet Age-related Macular Degeneration or Diabetic Macular Edema to Assess the freQuency of Use of Intravitreal Aflibercept in Routine Clinical Practices in Latin America

Start date: April 3, 2018
Study type: Observational

The main objectives of this observational cohort study are to describe the use of intravitreal aflibercept and to describe follow-up as well as treatment patterns in patients with wAMD or DME in routine clinical practice in Latin America for a study population of treatment naive patients and those who have received prior therapy (anti-VEGF injections, laser, steroids, etc.) and are being switched to intravitreal aflibercept injection.