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NCT ID: NCT03728881 Not yet recruiting - Cervical Cancer Clinical Trials

Immunogenicity From 1 Dose of Bivalent HPV Vaccine in Girls to 3 Doses of Quadrivalent Vaccine in Women: the PRIMAVERA-ESCUDDO Trial

Start date: January 18, 2019
Phase: Phase 3
Study type: Interventional

Background: Cervical cancer is a dangerous disease caused by a germ called human papillomavirus (HPV). There are 3 safe vaccines that protect women against HPV and cancer. Currently, girls receive 2 doses of HPV vaccine. Researchers want to test if only 1 dose is enough. This study in Costa Rica is one of several new 1-dose studies being done around the world. Objective: To find out if giving only 1 dose of the HPV vaccine Cervarix to young girls works the same as giving 3 doses of the HPV vaccine Gardasil to young women. Eligibility: Healthy girls ages 9-14 Healthy women ages 18-25 Design: Participants will be screened with blood and urine tests and questions about their health. Their parents may answer some of the questions. Participants will get the vaccine as an injection in the arm. They will be observed for 15 minutes each time they get the vaccine. Participants ages 9-14 will get the Cervarix vaccine 1 time. Six months later, participants (or their parents) will be asked about their health. This contact will be a phone call and will take about 5 minutes. Participants ages 18-25 will get the Gardasil vaccine 3 times over 6 months. All participants will have 1 half-hour visit every year for 3 years after getting the vaccine. This can be at the clinic or the participant s home. Participants and/or their parents will answer questions about the participant s health and any vaccines they received since the last contact. Participants will give a blood sample.

NCT ID: NCT03653364 Recruiting - Influenza Clinical Trials

Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants From Birth to < 1 Year With Influenza-Like Symptoms

Start date: December 13, 2018
Phase: Phase 3
Study type: Interventional

This study will evaluate the safety, pharmacokinetics and efficacy of baloxavir marboxil in healthy pediatric participants from birth to <1 year with influenza like symptoms

NCT ID: NCT03629184 Recruiting - Influenza Clinical Trials

Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms

Start date: November 20, 2018
Phase: Phase 3
Study type: Interventional

This study will evaluate the safety, pharmacokinetics, and efficacy of baloxavir marboxil compared with oseltamivir in a single influenza episode in otherwise healthy pediatric participants (i.e., 1 to <12 years of age) with influenza-like symptoms.

NCT ID: NCT03549754 Recruiting - Type 2 Diabetes Clinical Trials

DISCOVER Global Registry

Start date: February 17, 2018
Study type: Observational [Patient Registry]

To provide real world data on patient characteristics, disease management, healthcare utilization, and outcomes in patients with type 2 diabetes and established micro- and/or macrovascular disease

NCT ID: NCT03523858 Recruiting - Clinical trials for Progressive Multiple Sclerosis (PMS)

A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

Start date: May 28, 2018
Phase: Phase 3
Study type: Interventional

This study is a prospective, multicenter, open-label, single-arm effectiveness and safety study in participants with progressive multiple sclerosis (PMS).

NCT ID: NCT03492619 Completed - Obesity Clinical Trials

Intervention for Women in Costa Rica

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

The study develops, implements, and evaluates an intervention focused on alleviating discouragement, food insecurity, and excess weight in women,targeted at the individual, family, and community levels in the Canton Central of the province of Alajuela, Costa Rica.

NCT ID: NCT03470103 Recruiting - Clinical trials for Macular Degeneration

A Study in Patients With Wet Age-related Macular Degeneration or Diabetic Macular Edema to Assess the freQuency of Use of Intravitreal Aflibercept in Routine Clinical Practices in Latin America

Start date: April 3, 2018
Study type: Observational

The main objectives of this observational cohort study are to describe the use of intravitreal aflibercept and to describe follow-up as well as treatment patterns in patients with wAMD or DME in routine clinical practice in Latin America for a study population of treatment naive patients and those who have received prior therapy (anti-VEGF injections, laser, steroids, etc.) and are being switched to intravitreal aflibercept injection.

NCT ID: NCT03337724 Recruiting - Breast Cancer Clinical Trials

A Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Altered, Locally Advanced or Metastatic, Triple-Negative Breast Cancer or Hormone Receptor-Positive, HER2-Negative Breast Cancer

Start date: January 6, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

This study will evaluate the efficacy of ipatasertib + paclitaxel versus placebo + paclitaxel in participants with histologically confirmed, locally advanced or metastatic triple-negative breast cancer (TNBC) and in participants with locally advanced or metastatic hormone receptor positive (HR+)/ human epidermal growth factor receptor 2 negative (HER2−) breast adenocarcinoma who are not suitable for endocrine therapy.

NCT ID: NCT03309033 Enrolling by invitation - Cervical Cancer Clinical Trials

Fifteen-year Immunologic Follow-up of Women Who Received One, Two and Three Doses of the Bivalent HPV Vaccine in the Costa Rica HPV-16/18 Vaccine Trial (CVT): Generating Durability Data: The ESCUDDO-CVT Study

Start date: July 2, 2018
Study type: Observational

Background: HPV is the human papillomavirus. Women who get infected with it can get cervical cancer. The Costa Rica vaccine trial (CVT) studied an HPV vaccine for young women. A Long Term Follow Up (LTFU) study was done 10 years later. Researchers want to follow up with the women in these studies for 5 more years. This will help them learn more about the risks and benefits of the HPV vaccine. Objectives: To study anti-HPV-16/18 antibodies over the long term in women who got an HPV vaccinate. To study how antibody levels have changed depending on the dose and type of vaccine. Eligibility: Women in the original CVT LTFU study Design: Staff will contact participants from the CVT LTFU study. This will be done by phone or in person at home. Participants will be asked about participating in a new study. Participants who agree will have their first study visit and sign the informed consent document. Participants will answer questions about sexual behavior, smoking, contraceptives, and reproductive history. Participants will have blood collected. Study visits will be conducted either in a clinic or at home.

NCT ID: NCT03308838 Completed - Clinical trials for Myocardial Infarction, Acute

A Case-control Study of Costa Rican Adults With Myocardial Infarction

Start date: August 1, 1994
Phase: N/A
Study type: Observational

This observational case-control trial sought to identify and characterize different exposures associated with nonfatal acute myocardial infarction in Costa Rican adults. Exposures assessed included dietary variables and adipose tissue fatty acids.