Clinical Trials Logo

Filter by:
NCT ID: NCT03466411 Not yet recruiting - Crohn's Disease Clinical Trials

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

Start date: April 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this program is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.

NCT ID: NCT03450044 Recruiting - Clinical trials for Breast Cancer Female

Immunogenicity and Safety of DCs in Breast Cancer

Start date: January 2014
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to evaluate for the first time in Colombia the immunogenicity and safety of autologous DCs as enhancers of the immune response in patients with ductal breast cancer who, prior to surgical resection of the tumor, will receive neo-adjuvant chemotherapy with Doxorubicin and Cyclophosphamide. concomitantly with the transfer of autologous DCs. This clinical trial is based on the concept proposed in countries like France more than a decade ago, that chemotherapy or radiotherapy cause the tumor cells to release certain signals that favor the activation of the immune system against cancer. Therefore, the combined use of chemotherapy with vaccination with dendritic cells would provide the immune system with greater antitumor response capacity, taking advantage of the release of said signals to initiate a series of processes that would be reflected in the activation of T lymphocytes capable of destroying the remaining cells of the tumor. To determine the specificity of the response evoked by the adoptive transfer of autologous DCs, in each patient the degree of recognition of the tumor by the immune system before and after said procedure will be evaluated. These results will be compared with those of patients who participated in a control group. Hypothesis Adoptive transfer of autologous DCs generated in vitro, in patients with stage IIA-IV breast cancer who receive neoadjuvant therapy with Doxorubicin and Cyclophosphamide, is a safe procedure that stimulates anti-tumor immune responses in treated patients. Principal aim: To evaluate the safety and immunogenicity of the use of DCs when used in patients with stage IIA-IV breast cancer in association with neo-adjuvant chemotherapy with Doxorubicin/Cyclophosphamide. Specific aims: - Generate immuno-competent dendritic cells in conditions of Good Clinical Practice and Good Laboratory Practices. - Determine in each patient the immunological status of specific T lymphocytes against tumor antigens, before and after chemotherapy, in order to demonstrate whether the adoptive transfer of DCs favors the anti-tumor immune response. - Register in patients with breast cancer in neo-adjuvant chemotherapy the class and frequency of adverse effects that could be generated as a result of the adoptive transfer of autologous DCs.

NCT ID: NCT03444870 Not yet recruiting - Alzheimer Disease Clinical Trials

Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

Start date: July 31, 2018
Phase: Phase 3
Study type: Interventional

This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab versus placebo in participants with early AD. All participants must show evidence of β-amyloid pathology. Eligible participants will be randomized 1:1 to receive either subcutaneous (SC) injection of gantenerumab or placebo. The primary efficacy assessment will be performed at the end of the double blind period at week 104. Participants will then be offered to enter into an open-label extension (OLE). Participants not willing to go to the OLE will participate in a long term follow-up period for up to 50 weeks after the last gantenerumab dose.

NCT ID: NCT03433170 Recruiting - Clinical trials for Anterior Cruciate Ligament Injury

Quadrupled Semitendinosus Graft in Anterior Cruciate Ligament Reconstruction

Start date: January 20, 2018
Phase: N/A
Study type: Interventional

Randomized controlled trial comparing reconstruction of anterior cruciate ligament (ACL) with autologous quadrupled semitendinosus graft or with both semitendinosus and gracilis. It is intended to specially evaluate if by using only the semitendinosus (ST) tendon, the strength of the limb for hamstrings is affected different compared to using both gracilis and ST.

NCT ID: NCT03423914 Recruiting - Premature Infant Clinical Trials

Efficacy of Expressive Writing in Mothers of Preterm Infants

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

Premature birth can lead the mother to lose control of herself, and be a contributor to the psychological stress experienced due to the sudden breakdown of the interaction with her infant because of hospitalization in a neonatal care unit. This is a mixed method study, the aim is establish the effectiveness of expressive writing in the experience of mothers of hospitalized preterm infants. The intervention Expressive writing therapy could contribute to reduce the level of stress and anxiety, improving coping and the mother's interaction with her infant.

NCT ID: NCT03413033 Not yet recruiting - Voice Clinical Trials

Immediate Effects of Two Semi-occluded Vocal Tract Exercises

Start date: February 5, 2018
Phase: N/A
Study type: Observational

This study aims to observe the physiological effects of two different Semi-occluded vocal tract (SOVT) exercises in the larynx and pharynx when they are executed by individuals with constant vocal effort and without vocal pathology.

NCT ID: NCT03407482 Recruiting - Clinical trials for Lupus Erythematosus, Systemic

An Extension Study of GDC-0853 in Participants With Moderate to Severe Active Systemic Lupus Erythematosus

Start date: January 11, 2018
Phase: Phase 2
Study type: Interventional

This Phase II, multicenter, open-label extension (OLE) study will evaluate the long-term safety and efficacy of GDC-0853 in participants with systemic lupus erythematosus (SLE) who have completed Study GA30044 (NCT02908100) up to 48 weeks.

NCT ID: NCT03400449 Completed - Contraceptive Usage Clinical Trials

Video Versus Conversational Contraceptive Counseling During Maternity Hospitalization

Start date: April 28, 2015
Phase: N/A
Study type: Interventional

A randomized trial comparing LARC uptake and satisfaction after either video or conversational-based contraceptive counseling for pregnant women in labor.

NCT ID: NCT03393286 Recruiting - Zika Virus Clinical Trials

ZIKAlliance Children Cohort (ZIKAllianceCH)

Start date: January 15, 2018
Phase: N/A
Study type: Observational

The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations. We will estimate the absolute and relative risks of congenital malformations and other adverse outcomes of pregnancy among women who become infected with ZIKV during pregnancy compared to uninfected pregnant women, also leading to further validation of the Congenital Zika Syndrome.

NCT ID: NCT03389958 Completed - Contraception Clinical Trials

Maternity Care and Contraception

Start date: October 1, 2015
Phase: N/A
Study type: Observational

This is a multicenter observational study of implementation of postpartum contraceptive counseling and provision into the maternity care setting in Colombia, South America. The primary aim is to determine proportion of uptake of highly-effective contraceptive use after these methods become available immediately postpartum. Secondary aims include rapid repeat pregnancy rates, use of other types of contraception, breastfeeding continuation, and visualization of IUD strings after immediate postpartum placement.