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NCT ID: NCT01583439 Terminated - HIV Infections Clinical Trials

The Mochudi Prevention Project ART Protocol

Start date: September 2012
Phase: N/A
Study type: Interventional

The goal of the "Mochudi Prevention Project" is to reduce the number of new HIV infections in the village of Mochudi, Botswana by promoting a comprehensive package of interventions that have proven to be effective in preventing the spread of HIV. This antiretroviral treatment (ART) clinical study is nested within the Mochudi Prevention Project, and is being conducted in the north-east segment (NES) of the village of Mochudi. The ART intervention component of the Mochudi Project is designed to determine the uptake of, adherence to, and feasibility of 3-drug combination ART as a component of a package of transmission prevention strategies. The hypotheses are 1) that ART (with 3 antiretrovirals from two classes of drugs) among participants with CD4 ≥ 250 cells/mm3 and VL ≥ 50,000 cp/mL will be acceptable and safe and 2) Eighty percent of eligible participants will agree to start 3-drug ART.

NCT ID: NCT00111150 Terminated - HIV Infection Clinical Trials

Botswana Tenofovir Oral HIV Prophylaxis Trial

Start date: September 2005
Phase: Phase 2/Phase 3
Study type: Interventional

This study will test whether taking a pill of tenofovir (an antiretroviral medicine) is safe for sexually-active young adults in Botswana without HIV infection and whether it will reduce their risk of getting an HIV infection.

NCT ID: NCT00080119 Terminated - Tuberculosis Clinical Trials

Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV

Start date: February 2004
Phase: Phase 2/Phase 3
Study type: Interventional

Tuberculosis (TB) is highly endemic in sub-Saharan Africa. The increased burden of TB in settings with high prevalence of the Human Immunodeficiency Virus (HIV) is associated with high rates of transmission of Mycobacterium tuberculosis (M.tb) to both adults and children. Children infected with TB have a higher risk of developing severe disease than adults with TB. The purpose of this study was to determine if the antibiotic isoniazid (INH) prevented TB infection in infants born to HIV-infected mothers.